IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v454y2008i7204d10.1038_nature07085.html
   My bibliography  Save this article

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

Author

Listed:
  • Jamie M. Verheyden

    (Laboratory of Genetics, University of Wisconsin–Madison, Madison, Wisconsin 53706, USA)

  • Xin Sun

    (Laboratory of Genetics, University of Wisconsin–Madison, Madison, Wisconsin 53706, USA)

Abstract

Body size: when enough is enough The question of how a tissue grows to a certain size and knows when to stop remains a major mystery of biology. It is a phenomenon seen not only in body formation, but also in organs such as the liver when regeneration is allowed to occur. Many ideas have been proposed to explain how a tissue senses the limit of size, and few have been supported by experimental evidence. Jamie Verheyden and Xin Sun have discovered a new principle for control of organ size. In a study of the termination of signalling factors controlling growth and expansion in the mouse limb bud, a combination of mutations revealed an inhibitory loop whereby fibroblast growth factor (Fgf) signalling represses Gremlin1 expression, these two factors being key positive signals in limb bud outgrowth. This inhibitory loop is triggered by a positive Fgf/Shh loop. This model differs from earlier published models, and may have implications far beyond limb development, for size control in other organs, in evolution, and in limb regeneration.

Suggested Citation

  • Jamie M. Verheyden & Xin Sun, 2008. "An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth," Nature, Nature, vol. 454(7204), pages 638-641, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7204:d:10.1038_nature07085
    DOI: 10.1038/nature07085
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07085
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07085?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Eriko Tsuboi & Satomi F. Ono & Ingrid Rosenburg Cordeiro & Reiko Yu & Toru Kawanishi & Makoto Koizumi & Shuji Shigenobu & Guojun Sheng & Masataka Okabe & Mikiko Tanaka, 2024. "Immobilization secondary to cell death of muscle precursors with a dual transcriptional signature contributes to the emu wing skeletal pattern," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Sofia Sedas Perez & Caitlin McQueen & Holly Stainton & Joseph Pickering & Kavitha Chinnaiya & Patricia Saiz-Lopez & Marysia Placzek & Maria A. Ros & Matthew Towers, 2023. "Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:454:y:2008:i:7204:d:10.1038_nature07085. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.