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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

Author

Listed:
  • Tuomas Tammela

    (Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland)

  • Georgia Zarkada

    (Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland)

  • Elisabet Wallgard

    (Karolinska Institutet)

  • Aino Murtomäki

    (Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland)

  • Steven Suchting

    (Institut National de la Santé et de la Recherche Médicale U833, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France)

  • Maria Wirzenius

    (Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland)

  • Marika Waltari

    (Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland)

  • Mats Hellström

    (Karolinska Institutet)

  • Tibor Schomber

    (Center of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland)

  • Reetta Peltonen

    (Helsinki University Central Hospital, PO Box 263, 00029 Helsinki, Finland)

  • Catarina Freitas

    (Institut National de la Santé et de la Recherche Médicale U833, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France)

  • Antonio Duarte

    (The Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, Technical University of Lisbon)

  • Helena Isoniemi

    (Helsinki University Central Hospital, PO Box 263, 00029 Helsinki, Finland)

  • Pirjo Laakkonen

    (Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland)

  • Gerhard Christofori

    (Center of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland)

  • Seppo Ylä-Herttuala

    (University of Kuopio, PO Box 1627, 70211 Kuopio, Finland)

  • Masabumi Shibuya

    (Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan)

  • Bronislaw Pytowski

    (ImClone Systems, 180 Varick Street, New York 10014, USA)

  • Anne Eichmann

    (Institut National de la Santé et de la Recherche Médicale U833, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France)

  • Christer Betsholtz

    (Karolinska Institutet)

  • Kari Alitalo

    (Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland)

Abstract

Anti-angiogenesis: VEGFR-3 shows its paces The vascular endothelial growth factor (VEGF) receptor subtype VEGFR-3 is expressed only on lymphatic endothelium in adults. A new study, however, finds that VEGFR-3 is upregulated in the vasculature of tumours by Notch signalling. VEGFR-3 inhibition interferes with tumour angiogenesis and tumour growth, in particular in combination with inhibitors of VEGFR-2, suggesting that it represents a novel anti-angiogenic target for cancer therapy.

Suggested Citation

  • Tuomas Tammela & Georgia Zarkada & Elisabet Wallgard & Aino Murtomäki & Steven Suchting & Maria Wirzenius & Marika Waltari & Mats Hellström & Tibor Schomber & Reetta Peltonen & Catarina Freitas & Anto, 2008. "Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation," Nature, Nature, vol. 454(7204), pages 656-660, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7204:d:10.1038_nature07083
    DOI: 10.1038/nature07083
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    Cited by:

    1. Gregory Farber & Yanhan Dong & Qiaozi Wang & Mitesh Rathod & Haofei Wang & Michelle Dixit & Benjamin Keepers & Yifang Xie & Kendall Butz & William J. Polacheck & Jiandong Liu & Li Qian, 2024. "Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Frank A. Giordano & Julian P. Layer & Sonia Leonardelli & Lea L. Friker & Roberta Turiello & Dillon Corvino & Thomas Zeyen & Christina Schaub & Wolf Müller & Elena Sperk & Leonard Christopher Schmeel , 2024. "L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Maria Dzamukova & Tobias M. Brunner & Jadwiga Miotla-Zarebska & Frederik Heinrich & Laura Brylka & Mir-Farzin Mashreghi & Anjali Kusumbe & Ralf Kühn & Thorsten Schinke & Tonia L. Vincent & Max Löhning, 2022. "Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Jeremiah Bernier-Latmani & Cristina Mauri & Rachel Marcone & François Renevey & Stephan Durot & Liqun He & Michael Vanlandewijck & Catherine Maclachlan & Suzel Davanture & Nicola Zamboni & Graham W. K, 2022. "ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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