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Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Author

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  • Riina M. Luik

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Bin Wang

    (Stanford University School of Medicine, Stanford, California 94305, USA
    Present addresses: Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA (B.W.); Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (M.P.).)

  • Murali Prakriya

    (Stanford University School of Medicine, Stanford, California 94305, USA
    Present addresses: Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA (B.W.); Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (M.P.).)

  • Minnie M. Wu

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Richard S. Lewis

    (Stanford University School of Medicine, Stanford, California 94305, USA)

Abstract

Calcium in the endoplasmic reticulum STIM1 is the messenger that signals endoplasmic reticulum Ca2+ store depletion and subsequently activates the store-operated channel ORAI. However, its precise mechanism of action is unclear. Here, Luik et al. show that STIM oligomerzation, not the concentration of Ca2+ in the endoplasmic reticulum, is the key event that triggers ORAI activation.

Suggested Citation

  • Riina M. Luik & Bin Wang & Murali Prakriya & Minnie M. Wu & Richard S. Lewis, 2008. "Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation," Nature, Nature, vol. 454(7203), pages 538-542, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7203:d:10.1038_nature07065
    DOI: 10.1038/nature07065
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    Cited by:

    1. Huguette Croisier & Xiahui Tan & Jose F Perez-Zoghbi & Michael J Sanderson & James Sneyd & Bindi S Brook, 2013. "Activation of Store-Operated Calcium Entry in Airway Smooth Muscle Cells: Insight from a Mathematical Model," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-11, July.
    2. Paloma García Casas & Michela Rossini & Linnea Påvénius & Mezida Saeed & Nikita Arnst & Sonia Sonda & Tânia Fernandes & Irene D’Arsiè & Matteo Bruzzone & Valeria Berno & Andrea Raimondi & Maria Livia , 2024. "Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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