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Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

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  • Morgan E. Carlson

    (University of California, Berkeley, California 94720, USA)

  • Michael Hsu

    (University of California, Berkeley, California 94720, USA)

  • Irina M. Conboy

    (University of California, Berkeley, California 94720, USA)

Abstract

Making muscle young again The reduced ability of ageing muscle tissue to regenerate and repair itself has been found to result from high levels of TGF-β in the muscle stem cells, or satellite cells. Comparison of the muscle regeneration capacity of 2-year-old mice (equivalent to 75- to 80-year-old humans), with that of 2-month-old mice (equivalent to a 20- to 25-year-old) shows that success versus failure in muscle repair is determined by a balance between the levels of TGF-β/pSmad3 signalling and the activation of the Notch pathway. The work raises the possibility of developing therapeutic interventions to restore a stem-cell microniche in old muscle.

Suggested Citation

  • Morgan E. Carlson & Michael Hsu & Irina M. Conboy, 2008. "Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells," Nature, Nature, vol. 454(7203), pages 528-532, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7203:d:10.1038_nature07034
    DOI: 10.1038/nature07034
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    Cited by:

    1. Evelyn Zacharewicz & Paul Della Gatta & John Reynolds & Andrew Garnham & Tamsyn Crowley & Aaron P Russell & Séverine Lamon, 2014. "Identification of MicroRNAs Linked to Regulators of Muscle Protein Synthesis and Regeneration in Young and Old Skeletal Muscle," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-25, December.

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