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Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

Author

Listed:
  • Bin Zhou

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Qing Ma

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Satish Rajagopal

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Sean M. Wu

    (Harvard Stem Cell Institute, Harvard University and Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Ibrahim Domian

    (Harvard Stem Cell Institute, Harvard University and Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • José Rivera-Feliciano

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Dawei Jiang

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Alexander von Gise

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Clinic of Neonatology, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany)

  • Sadakatsu Ikeda

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Kenneth R. Chien

    (Harvard Stem Cell Institute, Harvard University and Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • William T. Pu

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

Abstract

Cardiac repair: New myocyte lineages Knowledge of the nature of cardiac progenitor cells is important for an understanding of the development of heart diseases, and as a potential route to regenerative therapy using stem cells. Two groups now report previously unknown cardiac myocyte lineages isolated from the proepicardium of the mouse. Cai et al. identify a population of progenitor cells that express the transcription factor Tbx18, and Zhou et al. identify cells marked by the transcription factor Wt1. Both types of progenitor are pluripotent, capable of producing several different classes of heart cell, making them promising candidates for use in cardiac repair.

Suggested Citation

  • Bin Zhou & Qing Ma & Satish Rajagopal & Sean M. Wu & Ibrahim Domian & José Rivera-Feliciano & Dawei Jiang & Alexander von Gise & Sadakatsu Ikeda & Kenneth R. Chien & William T. Pu, 2008. "Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart," Nature, Nature, vol. 454(7200), pages 109-113, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7200:d:10.1038_nature07060
    DOI: 10.1038/nature07060
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    Cited by:

    1. Karin D. Prummel & Helena L. Crowell & Susan Nieuwenhuize & Eline C. Brombacher & Stephan Daetwyler & Charlotte Soneson & Jelena Kresoja-Rakic & Agnese Kocere & Manuel Ronner & Alexander Ernst & Zahra, 2022. "Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Jeremy Lotto & Rebecca Cullum & Sibyl Drissler & Martin Arostegui & Victoria C. Garside & Bettina M. Fuglerud & Makenna Clement-Ranney & Avinash Thakur & T. Michael Underhill & Pamela A. Hoodless, 2023. "Cell diversity and plasticity during atrioventricular heart valve EMTs," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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