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Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins

Author

Listed:
  • Nathan HyunJoong Joh

    (UCLA-DOE Center for Genomics and Proteomics, Molecular Biology Institute)

  • Andrew Min

    (UCLA-DOE Center for Genomics and Proteomics, Molecular Biology Institute)

  • Salem Faham

    (and)

  • Julian P. Whitelegge

    (The NPI-Semel Institute, Pasarow Mass Spec Laboratory, University of California, Los Angeles, California 90095, USA)

  • Duan Yang

    (UCLA-DOE Center for Genomics and Proteomics, Molecular Biology Institute)

  • Virgil L. Woods

    (University of California, San Diego, La Jolla, California 92093-0656, USA)

  • James U. Bowie

    (UCLA-DOE Center for Genomics and Proteomics, Molecular Biology Institute)

Abstract

Side-chain stabilization in membrane proteins Hydrogen bonds have been widely assumed to be strongly stabilizing in membrane proteins, but there have been few experimental tests of this notion. In this work, interaction free energies were measured between eight hydrogen-bonded side chains in bacteriorhodopsin. Contrary to expectations, most make only modest stabilizing contributions, averaging 0.6 kcal mol−1. The results suggest that views of membrane protein folding, evolution and function should reflect such weak polar side-chain interactions.

Suggested Citation

  • Nathan HyunJoong Joh & Andrew Min & Salem Faham & Julian P. Whitelegge & Duan Yang & Virgil L. Woods & James U. Bowie, 2008. "Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins," Nature, Nature, vol. 453(7199), pages 1266-1270, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7199:d:10.1038_nature06977
    DOI: 10.1038/nature06977
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    Cited by:

    1. Alexander Bevacqua & Sachit Bakshi & Yu Xia, 2021. "Principal component analysis of alpha-helix deformations in transmembrane proteins," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-18, September.
    2. Wenqing Xu & Guanheng Huang & Zhan Yang & Ziqi Deng & Chen Zhou & Jian-An Li & Ming-De Li & Tao Hu & Ben Zhong Tang & David Lee Phillips, 2024. "Nucleic-acid-base photofunctional cocrystal for information security and antimicrobial applications," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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