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Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

Author

Listed:
  • Brian G. Fuller

    (University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA)

  • Michael A. Lampson

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Emily A. Foley

    (Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10021, USA)

  • Sara Rosasco-Nitcher

    (University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA)

  • Kim V. Le

    (University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Page Tobelmann

    (University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA)

  • David L. Brautigan

    (Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA)

  • P. Todd Stukenberg

    (University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA)

  • Tarun M. Kapoor

    (Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10021, USA)

Abstract

Mitotic regulation: A phosphorylation gradient in anaphase Aurora B, a kinase important in mitosis, is now shown to generate a spatial gradient of phosphorylated substrates in anaphase with the highest concentration at the spindle midzone. Generation of this gradient involves a microtubule-dependent mechanism of aurora B activation. The gradient is proposed to provide important spatial information during mitosis.

Suggested Citation

  • Brian G. Fuller & Michael A. Lampson & Emily A. Foley & Sara Rosasco-Nitcher & Kim V. Le & Page Tobelmann & David L. Brautigan & P. Todd Stukenberg & Tarun M. Kapoor, 2008. "Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient," Nature, Nature, vol. 453(7198), pages 1132-1136, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7198:d:10.1038_nature06923
    DOI: 10.1038/nature06923
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    Cited by:

    1. Susana Eibes & Girish Rajendraprasad & Claudia Guasch-Boldu & Mirela Kubat & Yulia Steblyanko & Marin Barisic, 2023. "CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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