IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v453y2008i7198d10.1038_nature06909.html
   My bibliography  Save this article

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

Author

Listed:
  • Ling-Bo Li

    (Department of Biology,
    Present address: Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112-5650, USA.)

  • Zhenming Yu

    (Department of Biology,
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA)

  • Xiuyin Teng

    (Department of Biology,
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA)

  • Nancy M. Bonini

    (Department of Biology,
    Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA)

Abstract

Ataxin-3 degeneration: An RNA-mediated component Polyglutamine (polyQ) diseases are a class of dominantly inherited neurodegenerative disorders caused by the expansion of a CAG repeat encoding glutamine within the coding region of the respective genes. PolyQ has traditionally been thought to cause neurodegeneration due to protein toxicity. In contrast, pathogenesis in other repeat diseases, such as myotonic dystrophy and fragile X-associated tremor/ataxia syndrome, is thought to result from the expression of toxic RNA repeats. Here they provide evidence that pathogenesis caused by ataxin-3, which contains CAG repeats, also involves an RNA-mediated component.

Suggested Citation

  • Ling-Bo Li & Zhenming Yu & Xiuyin Teng & Nancy M. Bonini, 2008. "RNA toxicity is a component of ataxin-3 degeneration in Drosophila," Nature, Nature, vol. 453(7198), pages 1107-1111, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7198:d:10.1038_nature06909
    DOI: 10.1038/nature06909
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06909
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06909?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Brett M. O’Brien & Roumita Moulick & Gabriel Jiménez-Avalos & Nandakumar Rajasekaran & Christian M. Kaiser & Sarah A. Woodson, 2024. "Stick-slip unfolding favors self-association of expanded HTT mRNA," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:453:y:2008:i:7198:d:10.1038_nature06909. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.