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Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

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  • Ryohei Sekido

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Robin Lovell-Badge

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

Abstract

Sex determination: A target for SRY The Sry gene, first cloned in 1990, was proven by mutation studies and sex reversal in transgenic mice to be the Y-linked mammalian testis-determining gene. Many other genes have since been implicated in early gonad development and in the decision to make testes or ovaries, but no proven direct target of SRY had been identified. Now a study of gene expression patterns in developing mouse embryos shows that the product of Sry, the testis-determining factor SRY, forms a complex with an orphan nuclear receptor SF1, and together they bind to an enhancer regulating Sox9, which is known to control the expression of genes involved in male development. Earlier work had suggested through studies of genetic interactions that Sox9 is a target of SRY. However, this study for the first time identifies a direct regulatory interaction at the level of transcriptional regulation, and identifies the enhancer element responsible.

Suggested Citation

  • Ryohei Sekido & Robin Lovell-Badge, 2008. "Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer," Nature, Nature, vol. 453(7197), pages 930-934, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature06944
    DOI: 10.1038/nature06944
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    Cited by:

    1. I. Szatkowska & M. Jedrzejczak-Silicka & A. Dybus & B. Wiszniewska & J. Udala & D. Zaborski & J. Wojcik & T. Stankiewicz & W.S. Proskura, 2017. "Expression profile of the SOX9 gene in the testes of sexually immature and mature male goats (Capra hircus), and its potential influence on postnatal testis development," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 62(5), pages 253-260.
    2. Steven C Munger & Anirudh Natarajan & Loren L Looger & Uwe Ohler & Blanche Capel, 2013. "Fine Time Course Expression Analysis Identifies Cascades of Activation and Repression and Maps a Putative Regulator of Mammalian Sex Determination," PLOS Genetics, Public Library of Science, vol. 9(7), pages 1-17, July.

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