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Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

Author

Listed:
  • Jennifer S. Ziegenfuss

    (University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA)

  • Romi Biswas

    (Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA)

  • Michelle A. Avery

    (University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA)

  • Kyoungja Hong

    (Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA)

  • Amy E. Sheehan

    (University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA)

  • Yee-Guide Yeung

    (Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA)

  • E. Richard Stanley

    (Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA)

  • Marc R. Freeman

    (University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA)

Abstract

Targeting apoptotic cells for clearance Rapid clearance of apoptotic cells by phagocytosis is essential to prevent inflammation. This paper shows that glial cell phagocytosis in Drosophila requires the interaction of the engulfment receptor Draper with the non-receptor tyrosine kinase Shark through ITAM-like motifs. The Src family kinase Src42a is shown to phosphorylate Draper and thought to promote Shark binding.

Suggested Citation

  • Jennifer S. Ziegenfuss & Romi Biswas & Michelle A. Avery & Kyoungja Hong & Amy E. Sheehan & Yee-Guide Yeung & E. Richard Stanley & Marc R. Freeman, 2008. "Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling," Nature, Nature, vol. 453(7197), pages 935-939, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_nature06901
    DOI: 10.1038/nature06901
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    Cited by:

    1. Yupu Wang & Ruiling Zhang & Sihao Huang & Parisa Tajalli Tehrani Valverde & Meike Lobb-Rabe & James Ashley & Lalanti Venkatasubramanian & Robert A. Carrillo, 2023. "Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Áron Szabó & Virág Vincze & Aishwarya Sanjay Chhatre & András Jipa & Sarolta Bognár & Katalin Eszter Varga & Poulami Banik & Adél Harmatos-Ürmösi & Lukas J. Neukomm & Gábor Juhász, 2023. "LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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