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An endogenous small interfering RNA pathway in Drosophila

Author

Listed:
  • Benjamin Czech

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Colin D. Malone

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Rui Zhou

    (Harvard Medical School, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Alexander Stark

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Catherine Schlingeheyde

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Monica Dus

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Norbert Perrimon

    (Harvard Medical School, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Manolis Kellis

    (Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA)

  • James A. Wohlschlegel

    (David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA)

  • Ravi Sachidanandam

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Gregory J. Hannon

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Julius Brennecke

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

Abstract

Endo-siRNAs in Drosophila In this work, Czech et al. identify a new class of small RNAs in Drosophila: endogenous short interfering RNAs (endo-siRNAs). These RNAs are present in both somatic and gonadal cells. Their processing is different than that of miRNAs or piRNAs; it requires Dcr2 and, unusually, Loqs, the Dcr1 partner, rather than R2D2, the usual partner of Dcr2. The processed endo-siRNAs are the first small RNAs found to associate preferentially with the Argonaute protein AGO2, and this complex targets genes that encode proteins as well as mobile elements.

Suggested Citation

  • Benjamin Czech & Colin D. Malone & Rui Zhou & Alexander Stark & Catherine Schlingeheyde & Monica Dus & Norbert Perrimon & Manolis Kellis & James A. Wohlschlegel & Ravi Sachidanandam & Gregory J. Hanno, 2008. "An endogenous small interfering RNA pathway in Drosophila," Nature, Nature, vol. 453(7196), pages 798-802, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7196:d:10.1038_nature07007
    DOI: 10.1038/nature07007
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    Cited by:

    1. Hejin Lai & Ning Feng & Qiwei Zhai, 2023. "Discovery of the major 15–30 nt mammalian small RNAs, their biogenesis and function," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Bert I. Crawford & Mary Jo Talley & Joshua Russman & James Riddle & Sabrina Torres & Troy Williams & Michelle S. Longworth, 2024. "Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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