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Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

Author

Listed:
  • Yoshinori Kawamura

    (Institute for Genome Research, University of Tokushima)

  • Kuniaki Saito

    (Institute for Genome Research, University of Tokushima
    Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan)

  • Taishin Kin

    (Computational Biology Research Center, Advanced Industrial Science and Technology)

  • Yukiteru Ono

    (Information and Mathematical Science Laboratory, Inc.)

  • Kiyoshi Asai

    (Computational Biology Research Center, Advanced Industrial Science and Technology
    Graduate School of Frontier Science, University of Tokyo)

  • Takafumi Sunohara

    (Institute for Genome Research, University of Tokushima)

  • Tomoko N. Okada

    (Institute for Genome Research, University of Tokushima
    Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan)

  • Mikiko C. Siomi

    (Institute for Genome Research, University of Tokushima
    Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST))

  • Haruhiko Siomi

    (Institute for Genome Research, University of Tokushima
    Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan)

Abstract

Endo-siRNAs in Drosophila Transposable elements have recently been shown to be active in somatic as well as germline cells. Recently, a class of small RNAs, piRNAs, was shown to be expressed from retrotransposons in germline cells and to mediate their transcriptional silencing. In this study, Kawamura et al. identify another class of small RNAs, endogenous siRNAs (endo-siRNAs), many of which are expressed from (and repress) retrotransposons, but in somatic cells. Interestingly, endo-siRNAs and piRNAs interact with different subfamilies of Argonaute proteins involved in RNA inhibition.

Suggested Citation

  • Yoshinori Kawamura & Kuniaki Saito & Taishin Kin & Yukiteru Ono & Kiyoshi Asai & Takafumi Sunohara & Tomoko N. Okada & Mikiko C. Siomi & Haruhiko Siomi, 2008. "Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells," Nature, Nature, vol. 453(7196), pages 793-797, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7196:d:10.1038_nature06938
    DOI: 10.1038/nature06938
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    Cited by:

    1. Tsubasa Tanaka & Tamaki Yano & Shingo Usuki & Yoko Seo & Kento Mizuta & Maho Okaguchi & Maki Yamaguchi & Kazuko Hanyu-Nakamura & Noriko Toyama-Sorimachi & Katja Brückner & Akira Nakamura, 2024. "Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi responses," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Bert I. Crawford & Mary Jo Talley & Joshua Russman & James Riddle & Sabrina Torres & Troy Williams & Michelle S. Longworth, 2024. "Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Marianne Yoth & Stéphanie Maupetit-Méhouas & Abdou Akkouche & Nathalie Gueguen & Benjamin Bertin & Silke Jensen & Emilie Brasset, 2023. "Reactivation of a somatic errantivirus and germline invasion in Drosophila ovaries," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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