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Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

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  • Toshiaki Watanabe

    (National Institute of Genetics, Research Organization of Information and Systems, Mishima 411-8540, Japan
    School of Life Science, The Graduate University for Advanced Studies (SOKENDAI))

  • Yasushi Totoki

    (Genome Annotation and Comparative Analysis Team, Computational and Experimental Systems Biology Group, and,
    Present address: MetaSystems Research Team, RIKEN Advanced Science Institute, Yokohama 230-0045, Japan.)

  • Atsushi Toyoda

    (Sequence Technology Team, RIKEN Genomic Sciences Center, Yokohama 230-0045, Japan)

  • Masahiro Kaneda

    (Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge
    Reproductive Biology and Technology Research Team, National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Tsukuba 305-0901, Japan)

  • Satomi Kuramochi-Miyagawa

    (Graduate School of Medicine and Frontier Biosciences, Osaka University)

  • Yayoi Obata

    (Tokyo University of Agriculture)

  • Hatsune Chiba

    (National Institute of Genetics, Research Organization of Information and Systems, Mishima 411-8540, Japan
    School of Life Science, The Graduate University for Advanced Studies (SOKENDAI))

  • Yuji Kohara

    (School of Life Science, The Graduate University for Advanced Studies (SOKENDAI)
    Genome Biology Laboratory, Center for Genetic Resource Information, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411-8540, Japan)

  • Tomohiro Kono

    (Tokyo University of Agriculture)

  • Toru Nakano

    (Graduate School of Medicine and Frontier Biosciences, Osaka University)

  • M. Azim Surani

    (Tokyo University of Agriculture)

  • Yoshiyuki Sakaki

    (Genome Annotation and Comparative Analysis Team, Computational and Experimental Systems Biology Group, and,
    Sequence Technology Team, RIKEN Genomic Sciences Center, Yokohama 230-0045, Japan)

  • Hiroyuki Sasaki

    (National Institute of Genetics, Research Organization of Information and Systems, Mishima 411-8540, Japan
    School of Life Science, The Graduate University for Advanced Studies (SOKENDAI))

Abstract

Pseudogenes: Not without influence Over evolutionary time, many genes undergo duplication and one copy accumulates mutations that render it non-functional. These 'pseudogenes' are generally thought to be rather uninteresting, dead-end pieces of the genome. Yet there now appears to be more to it than that. Two groups report in this issue on pseudogenes that can in fact influence gene expression. The mechanism involves pairing of RNA antisense transcripts from pseudogenes with the mRNAs of protein-coding genes, forming a duplex RNA that is processed into endogenous siRNAs.

Suggested Citation

  • Toshiaki Watanabe & Yasushi Totoki & Atsushi Toyoda & Masahiro Kaneda & Satomi Kuramochi-Miyagawa & Yayoi Obata & Hatsune Chiba & Yuji Kohara & Tomohiro Kono & Toru Nakano & M. Azim Surani & Yoshiyuki, 2008. "Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes," Nature, Nature, vol. 453(7194), pages 539-543, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7194:d:10.1038_nature06908
    DOI: 10.1038/nature06908
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    Cited by:

    1. Xiaolong Lv & Wen Xiao & Yana Lai & Zhaozhen Zhang & Hongdao Zhang & Chen Qiu & Li Hou & Qin Chen & Duanduan Wang & Yun Gao & Yuanyuan Song & Xinjia Shui & Qinghua Chen & Ruixin Qin & Shuang Liang & W, 2023. "The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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