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Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

Author

Listed:
  • Lei Yang

    (The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA)

  • Mark H. Soonpaa

    (Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Indiana 46202, USA)

  • Eric D. Adler

    (The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA)

  • Torsten K. Roepke

    (Weill Medical College of Cornell University, 520 East 70th Street, New York, New York 10021, USA)

  • Steven J. Kattman

    (McEwen Centre for Regenerative Medicine, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • Marion Kennedy

    (McEwen Centre for Regenerative Medicine, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • Els Henckaerts

    (King’s College London)

  • Kristina Bonham

    (VistaGen Therapeutics Inc., 384 Oyster Point Boulevard, Suite 8, San Francisco, California 94080, USA)

  • Geoffrey W. Abbott

    (Weill Medical College of Cornell University, 520 East 70th Street, New York, New York 10021, USA)

  • R. Michael Linden

    (The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    King’s College London)

  • Loren J. Field

    (Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Indiana 46202, USA)

  • Gordon M. Keller

    (The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    McEwen Centre for Regenerative Medicine, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

Abstract

Embryonic stem cells: Take heart from a growth factor cocktail A method for differentiation and isolation of one of the earliest human cardiac progenitors from human embryonic stem cells has been developed. By supplying a cocktail of growth factors at the appropriate stage of development, these cells can form cardiac, endothelial and vascular smooth muscle in vitro and, when transplanted, in vivo. When plated in culture, they can form populations of contracting cardiomyocytes. Transplantation of the cells into damaged mice hearts improved cardiac function. These cells will be useful for the study of cardiac development, and provide an enriched source of progenitors for engineering cardiovascular tissue in vitro and for transplantation to large animal models of heart disease.

Suggested Citation

  • Lei Yang & Mark H. Soonpaa & Eric D. Adler & Torsten K. Roepke & Steven J. Kattman & Marion Kennedy & Els Henckaerts & Kristina Bonham & Geoffrey W. Abbott & R. Michael Linden & Loren J. Field & Gordo, 2008. "Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population," Nature, Nature, vol. 453(7194), pages 524-528, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7194:d:10.1038_nature06894
    DOI: 10.1038/nature06894
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    Cited by:

    1. Mariana A. Branco & Tiago P. Dias & Joaquim M. S. Cabral & Perpetua Pinto-do-Ó & Maria Margarida Diogo, 2022. "Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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