IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v453y2008i7193d10.1038_nature07040.html
   My bibliography  Save this article

Stem-cell-based therapy and lessons from the heart

Author

Listed:
  • Robert Passier

    (Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8
    Leiden University Medical Centre, Einthovenweg 20)

  • Linda W. van Laake

    (Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8
    University Medical Center Utrecht, Heidelberglaan 100)

  • Christine L. Mummery

    (Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8
    Leiden University Medical Centre, Einthovenweg 20)

Abstract

The potential usefulness of human embryonic stem cells for therapy derives from their ability to form any cell in the body. This potential has been used to justify intensive research despite some ethical concerns. In parallel, scientists have searched for adult stem cells that can be used as an alternative to embryonic cells, and, for the heart at least, these efforts have led to promising results. However, most adult cardiomyocytes are unable to divide and form new cardiomyocytes and would therefore be unable to replace those lost as a result of disease. Basic questions — for example, whether cardiomyocyte replacement or alternatives, such as providing the damaged heart with new blood vessels or growth factors to activate resident stem cells, are the best approach — remain to be fully addressed. Despite this, preclinical studies on cardiomyocyte transplantation in animals and the first clinical trials with adult stem cells have recently been published with mixed results.

Suggested Citation

  • Robert Passier & Linda W. van Laake & Christine L. Mummery, 2008. "Stem-cell-based therapy and lessons from the heart," Nature, Nature, vol. 453(7193), pages 322-329, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7193:d:10.1038_nature07040
    DOI: 10.1038/nature07040
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07040
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07040?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. P. Sáez & E. Kuhl, 2016. "Computational modeling of acute myocardial infarction," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 19(10), pages 1107-1115, July.
    2. Wei Teng, Chih & Foley, Lucy & O'Neill, Peter & Hicks, Chris, 2014. "An analysis of supply chain strategies in the regenerative medicine industry—Implications for future development," International Journal of Production Economics, Elsevier, vol. 149(C), pages 211-225.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:453:y:2008:i:7193:d:10.1038_nature07040. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.