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Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal

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  • Leonard I. Zon

    (Children's Hospital Boston)

Abstract

When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically by gene expression in a cell-type-specific manner and is modulated through interactions with extrinsic cues from the environment, such as growth factors. However, despite the prevalence of the term self-renewal in the scientific literature, this process has not been defined at the molecular level. Haematopoietic stem cells are an excellent model for the study of self-renewal because they can be isolated prospectively, manipulated relatively easily and assessed by using well-defined assays. Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues.

Suggested Citation

  • Leonard I. Zon, 2008. "Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal," Nature, Nature, vol. 453(7193), pages 306-313, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7193:d:10.1038_nature07038
    DOI: 10.1038/nature07038
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    Cited by:

    1. Lorand Gabriel Parajdi & Radu Precup & Eduard Alexandru Bonci & Ciprian Tomuleasa, 2020. "A Mathematical Model of the Transition from Normal Hematopoiesis to the Chronic and Accelerated-Acute Stages in Myeloid Leukemia," Mathematics, MDPI, vol. 8(3), pages 1-18, March.

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