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Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

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  • Omobolaji O. Akala

    (Cellular and Molecular Biology Graduate Program, University of Michigan, 2966 Taubman Medical Library, Ann Arbor, Michigan 48109-0619, USA
    Internal Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, California 93404, USA)

  • In-Kyung Park

    (Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA)

  • Dalong Qian

    (Internal Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, California 93404, USA)

  • Michael Pihalja

    (Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA)

  • Michael W. Becker

    (University of Rochester, Rochester, New York 14642, USA)

  • Michael F. Clarke

    (Internal Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, California 93404, USA)

Abstract

Self-renewal in stem cells Stem cells maintain themselves over the life-time of an organism by their ability to self-renew. Multipotent progenitor cells are like stem cells in their ability to form many kinds of differentiated cells, but they do not self-renew and have a limited lifespan. Gene knock-out experiments in mice now show that by deleting just three genes, multipotent progenitor cells can be converted into long-term renewing cells. The normal role of the genes — p16Ink4a , p19Arf , and Tp53 — is to prevent progenitors from self-renewing. They are involved in pathways commonly repressed in cancer, pointing to a possible mechanism for tumorigenic mutation in progenitor cells.

Suggested Citation

  • Omobolaji O. Akala & In-Kyung Park & Dalong Qian & Michael Pihalja & Michael W. Becker & Michael F. Clarke, 2008. "Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors," Nature, Nature, vol. 453(7192), pages 228-232, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7192:d:10.1038_nature06869
    DOI: 10.1038/nature06869
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    Cited by:

    1. Huiru Bai & Xiaoqin Liu & Meizhen Lin & Yuan Meng & Ruolan Tang & Yajing Guo & Nan Li & Michael F. Clarke & Shang Cai, 2024. "Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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