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Chromatin decouples promoter threshold from dynamic range

Author

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  • Felix H. Lam

    (Howard Hughes Medical Institute, and Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 7 Divinity Avenue, Bauer 307, Cambridge, Massachusetts 02138, USA
    Graduate Group in Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • David J. Steger

    (Howard Hughes Medical Institute, and Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 7 Divinity Avenue, Bauer 307, Cambridge, Massachusetts 02138, USA
    Present address: Division of Endocrinology, Diabetes and Metabolism, 611 Clinical Research Building, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.)

  • Erin K. O’Shea

    (Howard Hughes Medical Institute, and Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 7 Divinity Avenue, Bauer 307, Cambridge, Massachusetts 02138, USA)

Abstract

By testing variants of the budding yeast phosphate response (PHO) genes, it is shown that the affinity of DNA binding sites that are accessible to a transcription factor determines the threshold for promoter activation, and that the binding sites within nucleosomal regions serve to influence the maximal expression of a gene once the nucleosomes are remodelled. Thus nucleosomes can decouple a promoter's threshold of activation from its dynamic range.

Suggested Citation

  • Felix H. Lam & David J. Steger & Erin K. O’Shea, 2008. "Chromatin decouples promoter threshold from dynamic range," Nature, Nature, vol. 453(7192), pages 246-250, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7192:d:10.1038_nature06867
    DOI: 10.1038/nature06867
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    Cited by:

    1. Amir Shahein & Maria López-Malo & Ivan Istomin & Evan J. Olson & Shiyu Cheng & Sebastian J. Maerkl, 2022. "Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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