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BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

Author

Listed:
  • Charles G. Mullighan

    (Departments of Pathology,)

  • Christopher B. Miller

    (Departments of Pathology,)

  • Ina Radtke

    (Departments of Pathology,)

  • Letha A. Phillips

    (Departments of Pathology,)

  • James Dalton

    (Departments of Pathology,)

  • Jing Ma

    (The Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA)

  • Deborah White

    (The Institute for Medical and Veterinary Science, Adelaide, South Australia 5000, Australia)

  • Timothy P. Hughes

    (The Institute for Medical and Veterinary Science, Adelaide, South Australia 5000, Australia)

  • Michelle M. Le Beau

    (Section of Hematology/Oncology, University of Chicago, Chicago, Illinois 60637, USA)

  • Ching-Hon Pui

    (Oncology and,)

  • Mary V. Relling

    (Pharmaceutical Sciences and,)

  • Sheila A. Shurtleff

    (Departments of Pathology,)

  • James R. Downing

    (Departments of Pathology,)

Abstract

Ikaros protein in ALL The Philadelphia chromosome is a genetic abnormality associated with chronic myelogenous leukaemia and some types of acute lymphoblastic leukaemia. It produces an abnormal signalling protein causing bone marrow cells to multiply uncontrollably. Now Mullighan et al. identify another mutant protein that contributes to this destructive process. Over 80% of a group of acute lymphoblastic leukaemia patients with the Philadelphia chromosome also lacked the gene IKZF1. The protein encoded by this gene is Ikaros, a lymphoid cell-specific transcription factor. The loss of Ikaros activity seems to cause a crucial malfunctioning that can contribute to the development of acute lymphoblastic leukaemia in the presence of the Philadelphia lesion.

Suggested Citation

  • Charles G. Mullighan & Christopher B. Miller & Ina Radtke & Letha A. Phillips & James Dalton & Jing Ma & Deborah White & Timothy P. Hughes & Michelle M. Le Beau & Ching-Hon Pui & Mary V. Relling & She, 2008. "BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros," Nature, Nature, vol. 453(7191), pages 110-114, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7191:d:10.1038_nature06866
    DOI: 10.1038/nature06866
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    Cited by:

    1. R. C. Nayak & K. H. Chang & A. K. Singh & M. Kotliar & M. Desai & A. M. Wellendorf & M. Wunderlich & J. Bartram & B. Mizukawa & M. Cuadrado & P. Dexheimer & A. Barski & X. R. Bustelo & N. N. Nassar & , 2022. "Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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