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The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus)

Author

Listed:
  • Ray Ming

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • Shaobin Hou

    (Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Yun Feng

    (TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, China
    Tianjin Research Center for Functional Genomics and Biochip, Tianjin Economic-Technological Development Area, Tianjin 300457, China)

  • Qingyi Yu

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA)

  • Alexandre Dionne-Laporte

    (Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Jimmy H. Saw

    (Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Pavel Senin

    (Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Wei Wang

    (TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, China
    Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, College of Life Sciences, Nankai University)

  • Benjamin V. Ly

    (Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Kanako L. T. Lewis

    (Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Steven L. Salzberg

    (Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA)

  • Lu Feng

    (TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, China
    Tianjin Research Center for Functional Genomics and Biochip, Tianjin Economic-Technological Development Area, Tianjin 300457, China
    Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, College of Life Sciences, Nankai University)

  • Meghan R. Jones

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA)

  • Rachel L. Skelton

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA)

  • Jan E. Murray

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • Cuixia Chen

    (University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • Wubin Qian

    (TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, China)

  • Junguo Shen

    (Tianjin Research Center for Functional Genomics and Biochip, Tianjin Economic-Technological Development Area, Tianjin 300457, China)

  • Peng Du

    (Tianjin Research Center for Functional Genomics and Biochip, Tianjin Economic-Technological Development Area, Tianjin 300457, China)

  • Moriah Eustice

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Eric Tong

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA)

  • Haibao Tang

    (Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA)

  • Eric Lyons

    (University of California, Berkeley, California 94720, USA)

  • Robert E. Paull

    (University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Todd P. Michael

    (Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA)

  • Kerr Wall

    (The Pennsylvania State University, University Park, Pennsylvania 16802, USA)

  • Danny W. Rice

    (Indiana University, Bloomington, Indiana 47405, USA)

  • Henrik Albert

    (USDA-ARS, Pacific Basin Agricultural Research Center, Hilo, Hawaii 96720, USA)

  • Ming-Li Wang

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA)

  • Yun J. Zhu

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA)

  • Michael Schatz

    (Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA)

  • Niranjan Nagarajan

    (Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA)

  • Ricelle A. Acob

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Peizhu Guan

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Andrea Blas

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Ching Man Wai

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Christine M. Ackerman

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA)

  • Yan Ren

    (TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, China)

  • Chao Liu

    (TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, China)

  • Jianmei Wang

    (TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, China)

  • Jianping Wang

    (University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • Jong-Kuk Na

    (University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • Eugene V. Shakirov

    (2128 TAMU, Texas A&M University, College Station, Texas 77843, USA)

  • Brian Haas

    (The Institute for Genomic Research, Rockville, Maryland 20850, USA)

  • Jyothi Thimmapuram

    (W.M. Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • David Nelson

    (University of Tennessee, Memphis, Tennessee 38163, USA)

  • Xiyin Wang

    (Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA)

  • John E. Bowers

    (Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA)

  • Andrea R. Gschwend

    (University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • Arthur L. Delcher

    (Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA)

  • Ratnesh Singh

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Jon Y. Suzuki

    (USDA-ARS, Pacific Basin Agricultural Research Center, Hilo, Hawaii 96720, USA)

  • Savarni Tripathi

    (USDA-ARS, Pacific Basin Agricultural Research Center, Hilo, Hawaii 96720, USA)

  • Kabi Neupane

    (Leeward Community College, University of Hawaii, Pearl City, Hawaii 96782, USA)

  • Hairong Wei

    (Wicell Research Institute, Madison, Wisconsin 53707, USA)

  • Beth Irikura

    (University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Maya Paidi

    (Hawaii Agriculture Research Center, Aiea, Hawaii 96701, USA
    University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Ning Jiang

    (Michigan State University, East Lansing, Michigan 48824, USA)

  • Wenli Zhang

    (University of Wisconsin, Madison, Wisconsin 53706, USA)

  • Gernot Presting

    (University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Aaron Windsor

    (Duke University, Durham, North Carolina 27708, USA)

  • Rafael Navajas-Pérez

    (Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA)

  • Manuel J. Torres

    (Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA)

  • F. Alex Feltus

    (Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA)

  • Brad Porter

    (University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Yingjun Li

    (University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • A. Max Burroughs

    (Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA)

  • Ming-Cheng Luo

    (University of California, Davis, California 95616, USA)

  • Lei Liu

    (W.M. Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • David A. Christopher

    (University of Hawaii, Honolulu, Hawaii 96822, USA)

  • Stephen M. Mount

    (Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland 20742, USA
    University of Maryland, College Park, Maryland 20742, USA)

  • Paul H. Moore

    (USDA-ARS, Pacific Basin Agricultural Research Center, Hilo, Hawaii 96720, USA)

  • Tak Sugimura

    (Maui High Performance Computing Center, Kihei, Hawaii 96753, USA)

  • Jiming Jiang

    (University of Wisconsin, Madison, Wisconsin 53706, USA)

  • Mary A. Schuler

    (Biochemistry and Plant Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA)

  • Vikki Friedman

    (Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA)

  • Thomas Mitchell-Olds

    (Duke University, Durham, North Carolina 27708, USA)

  • Dorothy E. Shippen

    (2128 TAMU, Texas A&M University, College Station, Texas 77843, USA)

  • Claude W. dePamphilis

    (The Pennsylvania State University, University Park, Pennsylvania 16802, USA)

  • Jeffrey D. Palmer

    (Indiana University, Bloomington, Indiana 47405, USA)

  • Michael Freeling

    (University of California, Berkeley, California 94720, USA)

  • Andrew H. Paterson

    (Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA)

  • Dennis Gonsalves

    (USDA-ARS, Pacific Basin Agricultural Research Center, Hilo, Hawaii 96720, USA)

  • Lei Wang

    (TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin Economic-Technological Development Area, Tianjin 300457, China
    Tianjin Research Center for Functional Genomics and Biochip, Tianjin Economic-Technological Development Area, Tianjin 300457, China
    Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, College of Life Sciences, Nankai University)

  • Maqsudul Alam

    (Advanced Studies in Genomics, Proteomics and Bioinformatics, University of Hawaii, Honolulu, Hawaii 96822, USA
    University of Hawaii, Honolulu, Hawaii 96822, USA)

Abstract

A transgenic crop genome In the early 1990s an outbreak of papaya ringspot virus (PRSV) in the papaya groves in the Puna district of Hawaii caused severe damage to an important crop. Since then, the planting of two transgenic cultivars resistant to the virus — called 'SunUp' and 'Rainbow' — has helped to maintain yields. SunUp is a transgenic red-fleshed fruit that expresses the coat protein gene of a mild mutant of PRSV, conferring resistance via post-transcriptional gene silencing. Rainbow is a yellow-fleshed (and therefore more popular) F1 hybrid bred from SunUp. Now the draft genome sequence of the SunUp strain of papaya has been determined — a first for a commercial virus-resistant transgenic fruit tree. Comparison of this plant genome to those of Arabidopsis and others sheds light on the evolution of qualities such as biosynthesis, starch deposition, control of photosynthesis and pathways for creating the volatile compounds that contribute to the characteristic flavour of papaya. On the cover, the disease-free transgenic Rainbow and the severely infected, stunted and dying non-transgenic Sunrise grow in adjoining plots.

Suggested Citation

  • Ray Ming & Shaobin Hou & Yun Feng & Qingyi Yu & Alexandre Dionne-Laporte & Jimmy H. Saw & Pavel Senin & Wei Wang & Benjamin V. Ly & Kanako L. T. Lewis & Steven L. Salzberg & Lu Feng & Meghan R. Jones , 2008. "The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus)," Nature, Nature, vol. 452(7190), pages 991-996, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7190:d:10.1038_nature06856
    DOI: 10.1038/nature06856
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    Cited by:

    1. G Fikre & A Mensa, 2021. "Evaluation of improved hermaphrodite papaya (Carica papaya L.) varieties at Arba Minch, Southern Ethiopia," International Journal of Agricultural Research, Innovation and Technology (IJARIT), IJARIT Research Foundation, vol. 11(2), December.
    2. Junhui Yuan & Sanjie Jiang & Jianbo Jian & Mingyu Liu & Zhen Yue & Jiabao Xu & Juan Li & Chunyan Xu & Lihong Lin & Yi Jing & Xiaoxiao Zhang & Haixin Chen & Linjuan Zhang & Tao Fu & Shuiyan Yu & Zhangy, 2022. "Genomic basis of the giga-chromosomes and giga-genome of tree peony Paeonia ostii," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Lima, R.S.N & García-Tejero, I. & Lopes, T.S. & Costa, J.M. & Vaz, M. & Durán-Zuazo, V.H. & Chaves, M. & Glenn, D.M. & Campostrini, E., 2016. "Linking thermal imaging to physiological indicators in Carica papaya L. under different watering regimes," Agricultural Water Management, Elsevier, vol. 164(P1), pages 148-157.
    4. Yongjun Fang & Xiaohu Xiao & Jishan Lin & Qiang Lin & Jiang Wang & Kaiye Liu & Zhonghua Li & Jianfeng Xing & Zhenglin Liu & Baiyu Wang & Yiying Qi & Xiangyu Long & Xia Zeng & Yanshi Hu & Jiyan Qi & Yu, 2024. "Pan-genome and phylogenomic analyses highlight Hevea species delineation and rubber trait evolution," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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