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Insect olfactory receptors are heteromeric ligand-gated ion channels

Author

Listed:
  • Koji Sato

    (The University of Tokyo)

  • Maurizio Pellegrino

    (Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York 10065, USA)

  • Takao Nakagawa

    (The University of Tokyo
    Present address: Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York 10065, USA.)

  • Tatsuro Nakagawa

    (The University of Tokyo)

  • Leslie B. Vosshall

    (Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York 10065, USA)

  • Kazushige Touhara

    (The University of Tokyo)

Abstract

Insect odorant receptors In many organisms, from worms to humans, olfactory cues are detected by large families of seven transmembrane-spanning receptors, which have until now been classified as G protein-coupled receptors. Insects, however, have evolved a surprisingly simple and efficient sense of smell in which the odorant receptors require a second component — the ion-channel-forming chaperone protein Or83b — for correct function. In the first of two related papers, Sato et al. show that these heteromeric receptors form ligand-gated cation channels that are not dependent on G protein-coupled second messengers, and speculate that other seven transmembrane-spanning proteins may show similar ion channel activity. Wicher et al. show that, in addition to direct channel activation, ligand binding to odorant receptors causes G protein-coupled channel activation. This work has implications for the search for insect odorant receptor inhibitors for possible use in controlling host seeking behaviour of disease carrying insects such as the mosquito.

Suggested Citation

  • Koji Sato & Maurizio Pellegrino & Takao Nakagawa & Tatsuro Nakagawa & Leslie B. Vosshall & Kazushige Touhara, 2008. "Insect olfactory receptors are heteromeric ligand-gated ion channels," Nature, Nature, vol. 452(7190), pages 1002-1006, April.
  • Handle: RePEc:nat:nature:v:452:y:2008:i:7190:d:10.1038_nature06850
    DOI: 10.1038/nature06850
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    Cited by:

    1. Jean-Pierre Rospars & Alexandre Grémiaux & David Jarriault & Antoine Chaffiol & Christelle Monsempes & Nina Deisig & Sylvia Anton & Philippe Lucas & Dominique Martinez, 2014. "Heterogeneity and Convergence of Olfactory First-Order Neurons Account for the High Speed and Sensitivity of Second-Order Neurons," PLOS Computational Biology, Public Library of Science, vol. 10(12), pages 1-16, December.
    2. Jody Pacalon & Guillaume Audic & Justine Magnat & Manon Philip & Jérôme Golebiowski & Christophe J. Moreau & Jérémie Topin, 2023. "Elucidation of the structural basis for ligand binding and translocation in conserved insect odorant receptor co-receptors," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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