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Molecular identification of a retinal cell type that responds to upward motion

Author

Listed:
  • In-Jung Kim

    (Harvard University, Cambridge, Massachusetts 02138, USA)

  • Yifeng Zhang

    (Harvard University, Cambridge, Massachusetts 02138, USA)

  • Masahito Yamagata

    (Harvard University, Cambridge, Massachusetts 02138, USA)

  • Markus Meister

    (Harvard University, Cambridge, Massachusetts 02138, USA)

  • Joshua R. Sanes

    (Harvard University, Cambridge, Massachusetts 02138, USA)

Abstract

Specialization in the retina The function of any neural circuit, such as the retina in the eye, is directly related to its connectivity, as determined by the functions of different classes of neuron and their choice of partners. Those attributes are governed by the genetic make up and molecular interactions of each neuron, but it has been difficult to demonstrate a continuous link from the genetic level to that of cellular structure and circuit function. In-Jung Kim et al. have developed a novel multidiscliplinary approach to the problem and apply it to retinal ganglion cells. They have discovered a new type of retinal neuron, identified by a genetic marker, with a unique cell shape, and a unique function. All cells of this type 'point' in a single direction. Remarkably, these cells respond best to objects moving in the direction predicted biophysically by their structure: upwards. The finding raises an intriguing question: why has the mouse invested so heavily in sensitivity to upward motion?

Suggested Citation

  • In-Jung Kim & Yifeng Zhang & Masahito Yamagata & Markus Meister & Joshua R. Sanes, 2008. "Molecular identification of a retinal cell type that responds to upward motion," Nature, Nature, vol. 452(7186), pages 478-482, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7186:d:10.1038_nature06739
    DOI: 10.1038/nature06739
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    Cited by:

    1. Donald R Cantrell & Jianhua Cang & John B Troy & Xiaorong Liu, 2010. "Non-Centered Spike-Triggered Covariance Analysis Reveals Neurotrophin-3 as a Developmental Regulator of Receptive Field Properties of ON-OFF Retinal Ganglion Cells," PLOS Computational Biology, Public Library of Science, vol. 6(10), pages 1-16, October.
    2. John A. Gaynes & Samuel A. Budoff & Michael J. Grybko & Joshua B. Hunt & Alon Poleg-Polsky, 2022. "Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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