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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Author

Listed:
  • Eriko Michishita

    (Gerontology and Metabolism, School of Medicine
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA)

  • Ronald A. McCord

    (Gerontology and Metabolism, School of Medicine
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA)

  • Elisabeth Berber

    (Gerontology and Metabolism, School of Medicine
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA)

  • Mitomu Kioi

    (School of Medicine)

  • Hesed Padilla-Nash

    (Genetics Branch, and,)

  • Mara Damian

    (Gerontology and Metabolism, School of Medicine
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA)

  • Peggie Cheung

    (and)

  • Rika Kusumoto

    (Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA)

  • Tiara L. A. Kawahara

    (Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, California 94305, USA)

  • J. Carl Barrett

    (Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, Maryland 20892, USA
    Present address: Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA.)

  • Howard Y. Chang

    (Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, California 94305, USA)

  • Vilhelm A. Bohr

    (Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA)

  • Thomas Ried

    (Genetics Branch, and,)

  • Or Gozani

    (and)

  • Katrin F. Chua

    (Gerontology and Metabolism, School of Medicine
    Geriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, California 94304, USA)

Abstract

The Sir2 family member SIRT6 is an NAD-dependent, histone H3 lysine 9 deacetylase enzyme that modulates telomeric chromatin and is required for stable association of WRN, the factor that is mutated in Werner Syndrome.

Suggested Citation

  • Eriko Michishita & Ronald A. McCord & Elisabeth Berber & Mitomu Kioi & Hesed Padilla-Nash & Mara Damian & Peggie Cheung & Rika Kusumoto & Tiara L. A. Kawahara & J. Carl Barrett & Howard Y. Chang & Vil, 2008. "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin," Nature, Nature, vol. 452(7186), pages 492-496, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7186:d:10.1038_nature06736
    DOI: 10.1038/nature06736
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    Cited by:

    1. Ming-liang Ji & Hua Jiang & Zhuang Li & Rui Geng & Jun Zheng Hu & Yu Cheng Lin & Jun Lu, 2022. "Sirt6 attenuates chondrocyte senescence and osteoarthritis progression," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Angelina M. Georgieva & Xinyue Guo & Marek Bartkuhn & Stefan Günther & Carsten Künne & Christian Smolka & Ann Atzberger & Ulrich Gärtner & Kamel Mamchaoui & Eva Bober & Yonggang Zhou & Xuejun Yuan & T, 2022. "Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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