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SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

Author

Listed:
  • Thomas F. Westbrook

    (Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics
    Present address: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.)

  • Guang Hu

    (Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics)

  • Xiaolu L. Ang

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Peter Mulligan

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Natalya N. Pavlova

    (Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics)

  • Anthony Liang

    (Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics)

  • Yumei Leng

    (Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics)

  • Rene Maehr

    (Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • Yang Shi

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • J. Wade Harper

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Stephen J. Elledge

    (Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics)

Abstract

The transcription factor REST plays important roles in opposing neuronal differentiation and in some human tumours. β-TrCP is identified as an important regulator of REST degradation.

Suggested Citation

  • Thomas F. Westbrook & Guang Hu & Xiaolu L. Ang & Peter Mulligan & Natalya N. Pavlova & Anthony Liang & Yumei Leng & Rene Maehr & Yang Shi & J. Wade Harper & Stephen J. Elledge, 2008. "SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation," Nature, Nature, vol. 452(7185), pages 370-374, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7185:d:10.1038_nature06780
    DOI: 10.1038/nature06780
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    Cited by:

    1. Debasish Paul & Stephen C. Kales & James A. Cornwell & Marwa M. Afifi & Ganesha Rai & Alexey Zakharov & Anton Simeonov & Steven D. Cappell, 2022. "Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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