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Thyrotrophin in the pars tuberalis triggers photoperiodic response

Author

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  • Nobuhiro Nakao

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Hiroko Ono

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Takashi Yamamura

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Tsubasa Anraku

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Tsuyoshi Takagi

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Kumiko Higashi

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Shinobu Yasuo

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Yasuhiro Katou

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Saburo Kageyama

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Yumiko Uno

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Takeya Kasukawa

    (Functional Genomics Subunit, Centre for Developmental Biology, RIKEN, 2-3-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan)

  • Masayuki Iigo

    (Faculty of Agriculture, Utsunomiya University, 350 Mine-machi, Utsunomiya, 321-8505, Japan)

  • Peter J. Sharp

    (Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9PS, UK)

  • Atsushi Iwasawa

    (Laboratory of Comparative Biochemistry, Graduate School of Applied Biological Sciences, Gifu University)

  • Yutaka Suzuki

    (Graduate School of Frontier Sciences, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan)

  • Sumio Sugano

    (Graduate School of Frontier Sciences, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan)

  • Teruyuki Niimi

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Makoto Mizutani

    (Avian Bioscience Research Centre, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Takao Namikawa

    (Avian Bioscience Research Centre, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Shizufumi Ebihara

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    Avian Bioscience Research Centre, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

  • Hiroki R. Ueda

    (Functional Genomics Subunit, Centre for Developmental Biology, RIKEN, 2-3-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
    Laboratory for Systems Biology, Centre for Developmental Biology, RIKEN, 2-3-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan)

  • Takashi Yoshimura

    (Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    Avian Bioscience Research Centre, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan)

Abstract

Molecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica) is the earliest event yet recorded in the photoperiodic signal transduction pathway. Here we show cascades of gene expression in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone. We identified two waves of gene expression. The first was initiated about 14 h after dawn of the first long day and included increased thyrotrophin (TSH) β-subunit expression in the pars tuberalis; the second occurred approximately 4 h later and included increased expression of DIO2. Intracerebroventricular (ICV) administration of TSH to short-day quail stimulated gonadal growth and expression of DIO2 which was shown to be mediated through a TSH receptor–cyclic AMP (cAMP) signalling pathway. Increased TSH in the pars tuberalis therefore seems to trigger long-day photoinduced seasonal breeding.

Suggested Citation

  • Nobuhiro Nakao & Hiroko Ono & Takashi Yamamura & Tsubasa Anraku & Tsuyoshi Takagi & Kumiko Higashi & Shinobu Yasuo & Yasuhiro Katou & Saburo Kageyama & Yumiko Uno & Takeya Kasukawa & Masayuki Iigo & P, 2008. "Thyrotrophin in the pars tuberalis triggers photoperiodic response," Nature, Nature, vol. 452(7185), pages 317-322, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7185:d:10.1038_nature06738
    DOI: 10.1038/nature06738
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    Cited by:

    1. Yusuke Nakane & Ai Shinomiya & Wataru Ota & Keisuke Ikegami & Tsuyoshi Shimmura & Sho-Ichi Higashi & Yasuhiro Kamei & Takashi Yoshimura, 2019. "Action spectrum for photoperiodic control of thyroid-stimulating hormone in Japanese quail (Coturnix japonica)," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-15, September.
    2. Sayaka Aizawa & Ichiro Sakata & Mai Nagasaka & Yuriko Higaki & Takafumi Sakai, 2013. "Negative Regulation of Neuromedin U mRNA Expression in the Rat Pars Tuberalis by Melatonin," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-9, July.

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