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Transcriptional repression mediated by repositioning of genes to the nuclear lamina

Author

Listed:
  • K. L. Reddy

    (Howard Hughes Medical Institute,
    The University of Chicago, GCIS W522, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • J. M. Zullo

    (Howard Hughes Medical Institute,
    The University of Chicago, GCIS W522, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • E. Bertolino

    (The University of Chicago, GCIS W522, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • H. Singh

    (Howard Hughes Medical Institute,
    The University of Chicago, GCIS W522, 929 East 57th Street, Chicago, Illinois 60637, USA)

Abstract

Artificially tethering a chromosomal region to the inner nuclear membrane (INM) of mammalian cells results in repression of gene transcription in conjunction with accumulation of lamin and INM proteins, but not nuclear pore complexes, at the tethered region.

Suggested Citation

  • K. L. Reddy & J. M. Zullo & E. Bertolino & H. Singh, 2008. "Transcriptional repression mediated by repositioning of genes to the nuclear lamina," Nature, Nature, vol. 452(7184), pages 243-247, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7184:d:10.1038_nature06727
    DOI: 10.1038/nature06727
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    Cited by:

    1. Yinuo Wang & Adel Elsherbiny & Linda Kessler & Julio Cordero & Haojie Shi & Heike Serke & Olga Lityagina & Felix A. Trogisch & Mona Malek Mohammadi & Ibrahim El-Battrawy & Johannes Backs & Thomas Wiel, 2022. "Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    2. Carlos Díaz-Castillo, 2013. "Females and Males Contribute in Opposite Ways to the Evolution of Gene Order in Drosophila," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.

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