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UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

Author

Listed:
  • You-Me Kim

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Melanie M. Brinkmann

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Marie-Eve Paquet

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • Hidde L. Ploegh

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA)

Abstract

The membrane protein UNC93B interacts with intracellular Toll-like receptors TLR7 and TLR9. This paper shows that UNC93B specifically controls TLR trafficking from the endoplasmic reticulum to the endolysosome but is not required for ligand recognition or signal initiation.

Suggested Citation

  • You-Me Kim & Melanie M. Brinkmann & Marie-Eve Paquet & Hidde L. Ploegh, 2008. "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes," Nature, Nature, vol. 452(7184), pages 234-238, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7184:d:10.1038_nature06726
    DOI: 10.1038/nature06726
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    Cited by:

    1. Yasunori Shintani & Hannes CA Drexler & Hidetaka Kioka & Cesare MN Terracciano & Steven R Coppen & Hiromi Imamura & Masaharu Akao & Junichi Nakai & Ann P Wheeler & Shuichiro Higo & Hiroyuki Nakayama &, 2014. "Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2," Nature, Nature, vol. 15(4), pages 438-445, April.
    2. Hai Ni & Yinuo Wang & Kai Yao & Ling Wang & Jiancheng Huang & Yongfang Xiao & Hongyao Chen & Bo Liu & Cliff Y. Yang & Jijun Zhao, 2024. "Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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