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A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing

Author

Listed:
  • Rouven Bingel-Erlenmeyer

    (Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland)

  • Rebecca Kohler

    (Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland)

  • Günter Kramer

    (Zentrum für Molekulare Biologie (ZMBH), Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Arzu Sandikci

    (Zentrum für Molekulare Biologie (ZMBH), Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Snježana Antolić

    (Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Present address: Solvias AG, Postfach, 4002 Basel, Switzerland.)

  • Timm Maier

    (Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland)

  • Christiane Schaffitzel

    (Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland)

  • Brigitte Wiedmann

    (Novartis Institutes for BioMedical Research, Inc., 500 Technology Square, Cambridge, Massachusetts, 02139, USA)

  • Bernd Bukau

    (Zentrum für Molekulare Biologie (ZMBH), Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Nenad Ban

    (Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland)

Abstract

This study determines how peptide deformylase interacts with the ribosome and how protein synthesis is coupled to processing of newly made proteins.

Suggested Citation

  • Rouven Bingel-Erlenmeyer & Rebecca Kohler & Günter Kramer & Arzu Sandikci & Snježana Antolić & Timm Maier & Christiane Schaffitzel & Brigitte Wiedmann & Bernd Bukau & Nenad Ban, 2008. "A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing," Nature, Nature, vol. 452(7183), pages 108-111, March.
  • Handle: RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06683
    DOI: 10.1038/nature06683
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    Cited by:

    1. Asuteka Nagao & Yui Nakanishi & Yutaro Yamaguchi & Yoshifumi Mishina & Minami Karoji & Takafumi Toya & Tomoya Fujita & Shintaro Iwasaki & Kenjyo Miyauchi & Yuriko Sakaguchi & Tsutomu Suzuki, 2023. "Quality control of protein synthesis in the early elongation stage," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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