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Multi-membrane hydrogels

Author

Listed:
  • Sébastien Ladet

    (Université de Lyon, Université Lyon 1, UMR CNRS 5223, Ingénierie des Matériaux Polymères (IMP), Laboratoire des Matériaux Polymères et des Biomatériaux, 15 Boulevard A. Latarjet, Bâtiment ISTIL, F-69622 Villeurbanne Cedex, France)

  • Laurent David

    (Université de Lyon, Université Lyon 1, UMR CNRS 5223, Ingénierie des Matériaux Polymères (IMP), Laboratoire des Matériaux Polymères et des Biomatériaux, 15 Boulevard A. Latarjet, Bâtiment ISTIL, F-69622 Villeurbanne Cedex, France)

  • Alain Domard

    (Université de Lyon, Université Lyon 1, UMR CNRS 5223, Ingénierie des Matériaux Polymères (IMP), Laboratoire des Matériaux Polymères et des Biomatériaux, 15 Boulevard A. Latarjet, Bâtiment ISTIL, F-69622 Villeurbanne Cedex, France)

Abstract

A tissue of hydrogels Polysaccharide-based hydrogels show potential for drug delivery and tissue engineering applications, for instance as a matrix to boost natural tissue regeneration. Ladet et al. use a multi-step interrupted gelation process to generate complex hydrogels with multi-membrane 'onion-like' and tubular architectures. The new structures are made from chitosan or alginates, biocompatible natural polymers, and their novel layered structure creates vacant 'inter-membrane' spaces suitable for cell or drug introduction. The starting hydrogel can have any shape, and in principle any number of layers can be created. Initial experiments with chondrocyte cells cultured within a chitosan hydrogel suggest that the material has potential as a base for artificial tissues.

Suggested Citation

  • Sébastien Ladet & Laurent David & Alain Domard, 2008. "Multi-membrane hydrogels," Nature, Nature, vol. 452(7183), pages 76-79, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06619
    DOI: 10.1038/nature06619
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    Cited by:

    1. Roberto Nisticò, 2017. "Aquatic-Derived Biomaterials for a Sustainable Future: A European Opportunity," Resources, MDPI, vol. 6(4), pages 1-15, November.

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