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The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

Author

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  • Nicole King

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,
    University of California, Berkeley, California 94720, USA)

  • M. Jody Westbrook

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Susan L. Young

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Alan Kuo

    (Walnut Creek, California 94598, USA)

  • Monika Abedin

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Jarrod Chapman

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Stephen Fairclough

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Uffe Hellsten

    (Walnut Creek, California 94598, USA)

  • Yoh Isogai

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Ivica Letunic

    (EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany)

  • Michael Marr

    (Brandeis University, Waltham, Massachusetts 02454, USA)

  • David Pincus

    (University of California, San Francisco, California 94158, USA)

  • Nicholas Putnam

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Antonis Rokas

    (Vanderbilt University, Nashville, Tennessee 37235, USA)

  • Kevin J. Wright

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Richard Zuzow

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • William Dirks

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Matthew Good

    (University of California, San Francisco, California 94158, USA)

  • David Goodstein

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Derek Lemons

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Wanqing Li

    (Stony Brook University, Stony Brook, New York 11794, USA)

  • Jessica B. Lyons

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Andrea Morris

    (University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Scott Nichols

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Daniel J. Richter

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Asaf Salamov

    (Walnut Creek, California 94598, USA)

  • JGI Sequencing

    (Walnut Creek, California 94598, USA)

  • Peer Bork

    (EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany)

  • Wendell A. Lim

    (University of California, San Francisco, California 94158, USA)

  • Gerard Manning

    (Razavi Newman Bioinformatics Center, Salk Institute for Biological Studies, La Jolla, California 92037, USA)

  • W. Todd Miller

    (Stony Brook University, Stony Brook, New York 11794, USA)

  • William McGinnis

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Harris Shapiro

    (Walnut Creek, California 94598, USA)

  • Robert Tjian

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,)

  • Igor V. Grigoriev

    (Walnut Creek, California 94598, USA)

  • Daniel Rokhsar

    (Department of Molecular and Cell Biology and the Center for Integrative Genomics,
    Walnut Creek, California 94598, USA)

Abstract

Choanoflagellates are the closest known relatives of metazoans. To discover potential molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome of the unicellular choanoflagellate Monosiga brevicollis. The genome contains approximately 9,200 intron-rich genes, including a number that encode cell adhesion and signalling protein domains that are otherwise restricted to metazoans. Here we show that the physical linkages among protein domains often differ between M. brevicollis and metazoans, suggesting that abundant domain shuffling followed the separation of the choanoflagellate and metazoan lineages. The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans.

Suggested Citation

  • Nicole King & M. Jody Westbrook & Susan L. Young & Alan Kuo & Monika Abedin & Jarrod Chapman & Stephen Fairclough & Uffe Hellsten & Yoh Isogai & Ivica Letunic & Michael Marr & David Pincus & Nicholas , 2008. "The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans," Nature, Nature, vol. 451(7180), pages 783-788, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7180:d:10.1038_nature06617
    DOI: 10.1038/nature06617
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    Cited by:

    1. Zhenjian Lin & Feng Li & Patrick J. Krug & Eric W. Schmidt, 2024. "The polyketide to fatty acid transition in the evolution of animal lipid metabolism," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. L. F. L. Wilson & T. Dendooven & S. W. Hardwick & A. Echevarría-Poza & T. Tryfona & K. B. R. M. Krogh & D. Y. Chirgadze & B. F. Luisi & D. T. Logan & K. Mani & P. Dupree, 2022. "The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Ya Gao & Daisylyn Senna Tan & Mathias Girbig & Haoqing Hu & Xiaomin Zhou & Qianwen Xie & Shi Wing Yeung & Kin Shing Lee & Sik Yin Ho & Vlad Cojocaru & Jian Yan & Georg K. A. Hochberg & Alex Mendoza & , 2024. "The emergence of Sox and POU transcription factors predates the origins of animal stem cells," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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