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Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling

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  • Sang-Dong Yoo

    (Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Young-Hee Cho

    (Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Guillaume Tena

    (Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Yan Xiong

    (Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Jen Sheen

    (Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

Abstract

A principal question in MAP kinase (MAPK/MPK) cascade signalling is how similar components dictate different specificity in the information-processing machineries from yeast to humans and plants. In Arabidopsis, how MPK3/6 modulates distinct outputs in diverse signal transduction pathways remains elusive. By combining systematic cellular and genetic screens, here we uncover a previously unexpected MKK9–MPK3/MPK6 cascade promoting ethylene-insensitive 3 (EIN3)-mediated transcription in ethylene signalling. The mkk9 mutant exhibits a broad spectrum of moderate ethylene-insensitive phenotypes, and translocated MKK9 governs nuclear signalling downstream of receptors. Breaking a linear model and conventional MAPK signalling, ethylene inactivates the negative regulator constitutive triple response 1 (CTR1, a Raf-like MAPK kinase kinase (MAPKKK)) to activate the positive MKK9–MPK3/6 cascade. The bifurcate and antagonistic CTR1 and MKK9 pathways are both critical in determining ethylene-signalling specificity through two MAPK phosphorylation sites with opposite effects on EIN3 stability. The results suggest a new paradigm for linking intertwined MAPK cascades to control quantitative responses and specificity in signalling networks.

Suggested Citation

  • Sang-Dong Yoo & Young-Hee Cho & Guillaume Tena & Yan Xiong & Jen Sheen, 2008. "Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling," Nature, Nature, vol. 451(7180), pages 789-795, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7180:d:10.1038_nature06543
    DOI: 10.1038/nature06543
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    Cited by:

    1. Chao He & Siteng Bi & Yuqi Li & Chengxiang Song & Heping Zhang & Xintong Xu & Qiang Li & Sulaiman Saeed & Wei Chen & Chunjie Zhao & Caixia Lan & Handong Su & Hailiang Mao & Wenhao Yan, 2024. "Dynamic atlas of histone modifications and gene regulatory networks in endosperm of bread wheat," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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