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Cell cycle control of centromeric repeat transcription and heterochromatin assembly

Author

Listed:
  • Ee Sin Chen

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Ke Zhang

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Estelle Nicolas

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Hugh P. Cam

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Martin Zofall

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Shiv I. S. Grewal

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

Abstract

RNA polymerase II transcribes heterochromatic repeat sequences preferentially during S-phase of the cell cycle, a timing that is enforced by heterochromatin restricting RNAPII access. Chromatin modifying enzymes and RNAi complexes associated with RNAPII then assemble silenced chromatin which is maintained until the next S phase.

Suggested Citation

  • Ee Sin Chen & Ke Zhang & Estelle Nicolas & Hugh P. Cam & Martin Zofall & Shiv I. S. Grewal, 2008. "Cell cycle control of centromeric repeat transcription and heterochromatin assembly," Nature, Nature, vol. 451(7179), pages 734-737, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7179:d:10.1038_nature06561
    DOI: 10.1038/nature06561
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    Cited by:

    1. Hyun-Soo Kim & Benjamin Roche & Sonali Bhattacharjee & Leila Todeschini & An-Yun Chang & Christopher Hammell & André Verdel & Robert A. Martienssen, 2024. "Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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