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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

Author

Listed:
  • Ken J. Ishii

    (Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST),
    Department of Molecular Protozoology,
    Laboratory of Host Defense, WPI Immunology Frontier Research Center,)

  • Tatsukata Kawagoe

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center,
    Department of Host Defense,)

  • Shohei Koyama

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center,
    Department of Host Defense,
    Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980-8575, Japan)

  • Kosuke Matsui

    (Department of Host Defense,)

  • Himanshu Kumar

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center,
    Department of Host Defense,)

  • Taro Kawai

    (Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST),
    Laboratory of Host Defense, WPI Immunology Frontier Research Center,
    Department of Host Defense,)

  • Satoshi Uematsu

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center,
    Department of Host Defense,)

  • Osamu Takeuchi

    (Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST),
    Laboratory of Host Defense, WPI Immunology Frontier Research Center,
    Department of Host Defense,)

  • Fumihiko Takeshita

    (Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan)

  • Cevayir Coban

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center,
    Department of Host Defense,
    The 21st Century Center of Excellence (COE), Combined Program on Microbiology and Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan)

  • Shizuo Akira

    (Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST),
    Laboratory of Host Defense, WPI Immunology Frontier Research Center,
    Department of Host Defense,
    The 21st Century Center of Excellence (COE), Combined Program on Microbiology and Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan)

Abstract

DNA vaccines induce adaptive immune responses mainly via induction of type-I interferon. This paper shows that this occurs by a mechanism that is independent of the activation of nucleic acid binding Toll-like receptors. B and CD4+ T cell responses require activation of the TBK pathway in hematopoietic cells, whereas TBK1 in non-hematopoietic cells is critical for the activation of CD8+ T cells.

Suggested Citation

  • Ken J. Ishii & Tatsukata Kawagoe & Shohei Koyama & Kosuke Matsui & Himanshu Kumar & Taro Kawai & Satoshi Uematsu & Osamu Takeuchi & Fumihiko Takeshita & Cevayir Coban & Shizuo Akira, 2008. "TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines," Nature, Nature, vol. 451(7179), pages 725-729, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7179:d:10.1038_nature06537
    DOI: 10.1038/nature06537
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    Cited by:

    1. Joo-Hui Han & Rajendra Karki & R. K. Subbarao Malireddi & Raghvendra Mall & Roman Sarkar & Bhesh Raj Sharma & Jonathon Klein & Harmut Berns & Harshan Pisharath & Shondra M. Pruett-Miller & Sung-Jin Ba, 2024. "NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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