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Lethargus is a Caenorhabditis elegans sleep-like state

Author

Listed:
  • David M. Raizen

    (Center for Sleep and Respiratory Neurobiology,
    Department of Neurology,)

  • John E. Zimmerman

    (Center for Sleep and Respiratory Neurobiology,)

  • Matthew H. Maycock

    (Center for Sleep and Respiratory Neurobiology,)

  • Uyen D. Ta

    (Center for Sleep and Respiratory Neurobiology,
    Department of Neurology,)

  • Young-jai You

    (University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA)

  • Meera V. Sundaram

    (Department of Genetics,)

  • Allan I. Pack

    (Center for Sleep and Respiratory Neurobiology,
    University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA)

Abstract

Sleeping with the worms Sleep research enters uncharted territory with the discovery of a sleep-like state in the nematode Caenorhabditis elegans. Sleep is vital in most animals but why this is so is largely unknown. The newly discovered quiescent behavioural state in C. elegans, called lethargus, displays many similarities with sleep as defined in mammals and, more recently, in Drosophila. Lethargus is regulated by a cyclic GMP signalling pathway, the first time this mechanism has been linked to sleep but probably not the last, since a similar pathway is conserved in Drosophila.

Suggested Citation

  • David M. Raizen & John E. Zimmerman & Matthew H. Maycock & Uyen D. Ta & Young-jai You & Meera V. Sundaram & Allan I. Pack, 2008. "Lethargus is a Caenorhabditis elegans sleep-like state," Nature, Nature, vol. 451(7178), pages 569-572, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7178:d:10.1038_nature06535
    DOI: 10.1038/nature06535
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    Cited by:

    1. Saurabh Thapliyal & Isabel Beets & Dominique A. Glauser, 2023. "Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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