IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v451y2008i7178d10.1038_nature06515.html
   My bibliography  Save this article

Negative regulation of the deacetylase SIRT1 by DBC1

Author

Listed:
  • Wenhui Zhao

    (Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA)

  • Jan-Philipp Kruse

    (Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA)

  • Yi Tang

    (Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA)

  • Sung Yun Jung

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Jun Qin

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Wei Gu

    (Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA)

Abstract

Linking ageing and cancer The deacetylase SIRT1, the mammalian version of the Sir2 protein that plays a critical role in determining lifespan in yeast, has been implicated in various cellular functions and possibly in tumorigenesis and ageing. The factors regulating SIRT1 are not well known but two groups now report that the tumour suppressor DBC1 is a negative regulator of SIRT1. By inhibiting SIRT1, DBC1 promotes increased acetylation of the tumour suppressor p53 and p53-mediated apoptosis in human cells.

Suggested Citation

  • Wenhui Zhao & Jan-Philipp Kruse & Yi Tang & Sung Yun Jung & Jun Qin & Wei Gu, 2008. "Negative regulation of the deacetylase SIRT1 by DBC1," Nature, Nature, vol. 451(7178), pages 587-590, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7178:d:10.1038_nature06515
    DOI: 10.1038/nature06515
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06515
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06515?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ana M Rojas & Anna Santamaria & Rainer Malik & Thomas Skøt Jensen & Roman Körner & Ian Morilla & David de Juan & Martin Krallinger & Daniel Aaen Hansen & Robert Hoffmann & Jonathan Lees & Adam Reid & , 2012. "Uncovering the Molecular Machinery of the Human Spindle—An Integration of Wet and Dry Systems Biology," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-16, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:451:y:2008:i:7178:d:10.1038_nature06515. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.