IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v451y2008i7177d10.1038_nature06469.html
   My bibliography  Save this article

Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina

Author

Listed:
  • Masahito Yamagata

    (Harvard University, Cambridge, Massachusetts 02138, USA)

  • Joshua R. Sanes

    (Harvard University, Cambridge, Massachusetts 02138, USA)

Abstract

Making connections Downs syndrome cell adhesion molecules (Dscams) are adhesion molecules of the immunoglolulin superfamily. Drosophila Dscams have been implicated in the organization of neural connectivity, but little is known about the functions of the closely related molecules in vertebrates. Masahito Yamagata and Joshua Sanes now demonstrate a role for Dscam and DscamL in patterning of lamina-specific connections in the chick retina. Two other adhesion molecules, called Sidekick-1 and Sidekick-2, act in a similar way. These molecules are widely distributed in the nervous system and may be part of an 'adhesive code' that patterns neural connections in the brain. Further evidence for the importance of Dscams in vertebrate neural patterning comes from Fuerst et al., who identify a role for DSCAM in establishing neural circuits in the retina of mice.

Suggested Citation

  • Masahito Yamagata & Joshua R. Sanes, 2008. "Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina," Nature, Nature, vol. 451(7177), pages 465-469, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7177:d:10.1038_nature06469
    DOI: 10.1038/nature06469
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06469
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06469?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Donald R Cantrell & Jianhua Cang & John B Troy & Xiaorong Liu, 2010. "Non-Centered Spike-Triggered Covariance Analysis Reveals Neurotrophin-3 as a Developmental Regulator of Receptive Field Properties of ON-OFF Retinal Ganglion Cells," PLOS Computational Biology, Public Library of Science, vol. 6(10), pages 1-16, October.
    2. Ken-ichi Dewa & Nariko Arimura & Wataru Kakegawa & Masayuki Itoh & Toma Adachi & Satoshi Miyashita & Yukiko U. Inoue & Kento Hizawa & Kei Hori & Natsumi Honjoya & Haruya Yagishita & Shinichiro Taya & , 2024. "Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:451:y:2008:i:7177:d:10.1038_nature06469. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.