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Identification of cells initiating human melanomas

Author

Listed:
  • Tobias Schatton

    (Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • George F. Murphy

    (Department of Pathology and,)

  • Natasha Y. Frank

    (Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Kazuhiro Yamaura

    (Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Ana Maria Waaga-Gasser

    (University of Würzburg Medical School)

  • Martin Gasser

    (University of Würzburg Medical School)

  • Qian Zhan

    (Department of Pathology and,)

  • Stefan Jordan

    (Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Lyn M. Duncan

    (Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Carsten Weishaupt

    (Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA)

  • Robert C. Fuhlbrigge

    (Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA)

  • Thomas S. Kupper

    (Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA)

  • Mohamed H. Sayegh

    (Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Markus H. Frank

    (Transplantation Research Center, Children’s Hospital Boston and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Melanoma stem cells Cancer stem cells have been isolated from a number of human tumours. The latest example is a subpopulation of human malignant melanoma initiating cells, identified by their expression of the chemoresistance mediator ABCB5. The size of the ABCB5+ subpopulations correlates with clinical disease progression in patients with melanomas, and preliminary evidence also suggests that these melanoma stem cells can be specifically targeted with antibodies against ABCB5. This offers a potential therapeutic strategy against melanomas, and the study of cells of this type could help answer important questions in cancer biology. The hybrid melanoma cell shown on the cover, depicted as a merged, computer-enhanced fluorescent microscopy image, arose in vivo in a human tumour xenograft through fusion of an ABCB5+ melanoma stem cell with a more differentiated, ABCB5− tumour cell. Nuclei are marked by genetically encoded red (DsRed) and green (EYFP) fluorescent labels, respectively.

Suggested Citation

  • Tobias Schatton & George F. Murphy & Natasha Y. Frank & Kazuhiro Yamaura & Ana Maria Waaga-Gasser & Martin Gasser & Qian Zhan & Stefan Jordan & Lyn M. Duncan & Carsten Weishaupt & Robert C. Fuhlbrigge, 2008. "Identification of cells initiating human melanomas," Nature, Nature, vol. 451(7176), pages 345-349, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06489
    DOI: 10.1038/nature06489
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    Cited by:

    1. Farshad Farshidfar & Kahn Rhrissorrakrai & Chaya Levovitz & Cong Peng & James Knight & Antonella Bacchiocchi & Juan Su & Mingzhu Yin & Mario Sznol & Stephan Ariyan & James Clune & Kelly Olino & Laxmi , 2022. "Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Junho Lee & Jin Su Kim & Yangjin Kim, 2021. "Atorvastatin-mediated rescue of cancer-related cognitive changes in combined anticancer therapies," PLOS Computational Biology, Public Library of Science, vol. 17(10), pages 1-28, October.

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