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The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal

Author

Listed:
  • Atilio Deana

    (Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Helena Celesnik

    (Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Joel G. Belasco

    (Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA)

Abstract

Degradation of bacterial mRNAs involves internal cleavage events, but internal cleavage is prevented until the 5' triphosphate of the mRNA is converted to a monophosphate. However, the identity of this pyrophosphatase was unknown. This work shows that the product of the NudH gene (now called RppH) possesses this activity and accelerates mRNA degradation in vivo. This enzyme is a member of the Nudix family of pyrophosphohydrolases.

Suggested Citation

  • Atilio Deana & Helena Celesnik & Joel G. Belasco, 2008. "The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal," Nature, Nature, vol. 451(7176), pages 355-358, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06475
    DOI: 10.1038/nature06475
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    Cited by:

    1. Beatrice T. Laudenbach & Karsten Krey & Quirin Emslander & Line Lykke Andersen & Alexander Reim & Pietro Scaturro & Sarah Mundigl & Christopher Dächert & Katrin Manske & Markus Moser & Janos Ludwig & , 2021. "NUDT2 initiates viral RNA degradation by removal of 5′-phosphates," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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