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Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

Author

Listed:
  • Miguel A. Sanjuan

    (Department of Immunology,)

  • Christopher P. Dillon

    (Department of Immunology,)

  • Stephen W. G. Tait

    (Department of Immunology,)

  • Simon Moshiach

    (and)

  • Frank Dorsey

    (St Jude Children’s Research Institute, Memphis, Tennessee 38105, USA)

  • Samuel Connell

    (Department of Immunology,)

  • Masaaki Komatsu

    (Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Tokyo 113-8613, Japan)

  • Keiji Tanaka

    (Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Tokyo 113-8613, Japan)

  • John L. Cleveland

    (The Scripps Research Institute, Jupiter, Florida 33458, USA)

  • Sebo Withoff

    (Department of Immunology,)

  • Douglas R. Green

    (Department of Immunology,)

Abstract

Autophagy contributes to host defence against infection. Toll like-receptor signals induce the recruitment of components of the autophagy pathway to phagosomes and facilitate phagosome lysosome fusion, resulting in killing of the invading organism.

Suggested Citation

  • Miguel A. Sanjuan & Christopher P. Dillon & Stephen W. G. Tait & Simon Moshiach & Frank Dorsey & Samuel Connell & Masaaki Komatsu & Keiji Tanaka & John L. Cleveland & Sebo Withoff & Douglas R. Green, 2007. "Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis," Nature, Nature, vol. 450(7173), pages 1253-1257, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7173:d:10.1038_nature06421
    DOI: 10.1038/nature06421
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    Cited by:

    1. Tian Zhou & Yuxin Li & Xiaoyu Li & Fanzhuo Zeng & Yanxia Rao & Yang He & Yafei Wang & Meizhen Liu & Dali Li & Zhen Xu & Xin Zhou & Siling Du & Fugui Niu & Jiyun Peng & Xifan Mei & Sheng-Jian Ji & Yous, 2022. "Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Catherine J. Greene & Jenny A. Nguyen & Samuel M. Cheung & Corey R. Arnold & Dale R. Balce & Ya Ting Wang & Adrian Soderholm & Neil McKenna & Devin Aggarwal & Rhiannon I. Campden & Benjamin W. Ewanchu, 2022. "Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Sharon Ben-Hur & Shoshana Sernik & Sara Afar & Alina Kolpakova & Yoav Politi & Liron Gal & Anat Florentin & Ofra Golani & Ehud Sivan & Nili Dezorella & David Morgenstern & Shmuel Pietrokovski & Eyal S, 2024. "Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization," Nature Communications, Nature, vol. 15(1), pages 1-25, December.

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