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Dynamic personalities of proteins

Author

Listed:
  • Katherine Henzler-Wildman

    (Howard Hughes Medical Institute, Brandeis University)

  • Dorothee Kern

    (Howard Hughes Medical Institute, Brandeis University)

Abstract

Because proteins are central to cellular function, researchers have sought to uncover the secrets of how these complex macromolecules execute such a fascinating variety of functions. Although static structures are known for many proteins, the functions of proteins are governed ultimately by their dynamic character (or 'personality'). The dream is to 'watch' proteins in action in real time at atomic resolution. This requires addition of a fourth dimension, time, to structural biology so that the positions in space and time of all atoms in a protein can be described in detail.

Suggested Citation

  • Katherine Henzler-Wildman & Dorothee Kern, 2007. "Dynamic personalities of proteins," Nature, Nature, vol. 450(7172), pages 964-972, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7172:d:10.1038_nature06522
    DOI: 10.1038/nature06522
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