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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Author

Listed:
  • Sergey Nejentsev

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Joanna M. M. Howson

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Neil M. Walker

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Jeffrey Szeszko

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Sarah F. Field

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Helen E. Stevens

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Pamela Reynolds

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Matthew Hardy

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Erna King

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Jennifer Masters

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • John Hulme

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Lisa M. Maier

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Deborah Smyth

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Rebecca Bailey

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Jason D. Cooper

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Gloria Ribas

    (MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, CB10 1SB, UK)

  • R. Duncan Campbell

    (MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, CB10 1SB, UK
    University of Oxford)

  • David G. Clayton

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • John A. Todd

Abstract

Diabetes The MHC complex, occupying a sizeable section of human chromosome 6, is linked to almost all known autoimmune disorders. A new study uses a large data set from the Wellcome Trust Case Control Consortium to focus more closely on the MHC genes linked to a specific disease, childhood diabetes. Two susceptibility genes emerge: HLA-A and HLA-B. The discovery clarifies the aetiology of type 1 diabetes and points to a class of peptides worth studying in the search for vaccination strategies.

Suggested Citation

  • Sergey Nejentsev & Joanna M. M. Howson & Neil M. Walker & Jeffrey Szeszko & Sarah F. Field & Helen E. Stevens & Pamela Reynolds & Matthew Hardy & Erna King & Jennifer Masters & John Hulme & Lisa M. Ma, 2007. "Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A," Nature, Nature, vol. 450(7171), pages 887-892, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7171:d:10.1038_nature06406
    DOI: 10.1038/nature06406
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    Cited by:

    1. Vikash Chandra & Hazem Ibrahim & Clémentine Halliez & Rashmi B. Prasad & Federica Vecchio & Om Prakash Dwivedi & Jouni Kvist & Diego Balboa & Jonna Saarimäki-Vire & Hossam Montaser & Tom Barsby & Väin, 2022. "The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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