IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v450y2007i7171d10.1038_nature06406.html
   My bibliography  Save this article

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Author

Listed:
  • Sergey Nejentsev

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Joanna M. M. Howson

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Neil M. Walker

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Jeffrey Szeszko

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Sarah F. Field

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Helen E. Stevens

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Pamela Reynolds

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Matthew Hardy

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Erna King

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Jennifer Masters

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • John Hulme

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Lisa M. Maier

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Deborah Smyth

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Rebecca Bailey

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Jason D. Cooper

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • Gloria Ribas

    (MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, CB10 1SB, UK)

  • R. Duncan Campbell

    (MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, CB10 1SB, UK
    University of Oxford)

  • David G. Clayton

    (Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge)

  • John A. Todd

Abstract

Diabetes The MHC complex, occupying a sizeable section of human chromosome 6, is linked to almost all known autoimmune disorders. A new study uses a large data set from the Wellcome Trust Case Control Consortium to focus more closely on the MHC genes linked to a specific disease, childhood diabetes. Two susceptibility genes emerge: HLA-A and HLA-B. The discovery clarifies the aetiology of type 1 diabetes and points to a class of peptides worth studying in the search for vaccination strategies.

Suggested Citation

  • Sergey Nejentsev & Joanna M. M. Howson & Neil M. Walker & Jeffrey Szeszko & Sarah F. Field & Helen E. Stevens & Pamela Reynolds & Matthew Hardy & Erna King & Jennifer Masters & John Hulme & Lisa M. Ma, 2007. "Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A," Nature, Nature, vol. 450(7171), pages 887-892, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7171:d:10.1038_nature06406
    DOI: 10.1038/nature06406
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06406
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06406?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alexia Carré & Fatoumata Samassa & Zhicheng Zhou & Javier Perez-Hernandez & Christiana Lekka & Anthony Manganaro & Masaya Oshima & Hanqing Liao & Robert Parker & Annalisa Nicastri & Barbara Brandao & , 2025. "Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    2. Vikash Chandra & Hazem Ibrahim & Clémentine Halliez & Rashmi B. Prasad & Federica Vecchio & Om Prakash Dwivedi & Jouni Kvist & Diego Balboa & Jonna Saarimäki-Vire & Hossam Montaser & Tom Barsby & Väin, 2022. "The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:450:y:2007:i:7171:d:10.1038_nature06406. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.