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Characterizing the cancer genome in lung adenocarcinoma

Author

Listed:
  • Barbara A. Weir

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Michele S. Woo

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • Gad Getz

    (Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Sven Perner

    (Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
    Institute of Pathology, University of Ulm)

  • Li Ding

    (Genome Sequencing Center,)

  • Rameen Beroukhim

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • William M. Lin

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Michael A. Province

    (Division of Statistical Genomics and,)

  • Aldi Kraja

    (Division of Statistical Genomics and,)

  • Laura A. Johnson

    (Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA)

  • Kinjal Shah

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Mitsuo Sato

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Roman K. Thomas

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max-Planck Society and the Medical Faculty of the University of Cologne
    University of Cologne)

  • Justine A. Barletta

    (Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA)

  • Ingrid B. Borecki

    (Division of Statistical Genomics and,)

  • Stephen Broderick

    (Surgery, Pathology, and Computational Biology
    Human Oncology and Pathogenesis Program,)

  • Andrew C. Chang

    (Section of Thoracic Surgery)

  • Derek Y. Chiang

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Lucian R. Chirieac

    (Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
    Department of Pathology and,)

  • Jeonghee Cho

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • Yoshitaka Fujii

    (Nagoya City University Medical School)

  • Adi F. Gazdar

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Thomas Giordano

    (University of Michigan, Ann Arbor, Michigan 48109, USA)

  • Heidi Greulich

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Megan Hanna

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Bruce E. Johnson

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • Mark G. Kris

    (Surgery, Pathology, and Computational Biology)

  • Alex Lash

    (Surgery, Pathology, and Computational Biology)

  • Ling Lin

    (Genome Sequencing Center,)

  • Neal Lindeman

    (Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
    Department of Pathology and,)

  • Elaine R. Mardis

    (Genome Sequencing Center,)

  • John D. McPherson

    (Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA)

  • John D. Minna

    (University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA)

  • Margaret B. Morgan

    (Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Mark Nadel

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Mark B. Orringer

    (Section of Thoracic Surgery)

  • John R. Osborne

    (Genome Sequencing Center,)

  • Brad Ozenberger

    (National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Alex H. Ramos

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • James Robinson

    (Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Jack A. Roth

    (Department of Thoracic and Cardiovascular Surgery,)

  • Valerie Rusch

    (Surgery, Pathology, and Computational Biology)

  • Hidefumi Sasaki

    (Nagoya City University Medical School)

  • Frances Shepherd

    (University Health Network and Princess Margaret Hospital)

  • Carrie Sougnez

    (Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Margaret R. Spitz

    (Department of Epidemiology,)

  • Ming-Sound Tsao

    (University Health Network and Princess Margaret Hospital)

  • David Twomey

    (Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Roel G. W. Verhaak

    (Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • George M. Weinstock

    (Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA)

  • David A. Wheeler

    (Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Wendy Winckler

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Akihiko Yoshizawa

    (Surgery, Pathology, and Computational Biology)

  • Soyoung Yu

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • Maureen F. Zakowski

    (Surgery, Pathology, and Computational Biology)

  • Qunyuan Zhang

    (Division of Statistical Genomics and,)

  • David G. Beer

    (Section of Thoracic Surgery)

  • Ignacio I. Wistuba

    (Department of Pathology and,
    The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA)

  • Mark A. Watson

    (Washington University in Saint Louis, Saint Louis, Missouri 63130, USA)

  • Levi A. Garraway

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Marc Ladanyi

    (Surgery, Pathology, and Computational Biology
    Human Oncology and Pathogenesis Program,)

  • William D. Travis

    (Surgery, Pathology, and Computational Biology)

  • William Pao

    (Surgery, Pathology, and Computational Biology
    Human Oncology and Pathogenesis Program,)

  • Mark A. Rubin

    (Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA)

  • Stacey B. Gabriel

    (Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA)

  • Richard A. Gibbs

    (Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Harold E. Varmus

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA)

  • Richard K. Wilson

    (Genome Sequencing Center,)

  • Eric S. Lander

    (Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA)

  • Matthew Meyerson

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Program, Genetic Analysis Platform, and Genome Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Department of Pathology and,)

Abstract

Oncogene unmasked A wide-ranging overview of genetic alterations in lung adenocarcinomas, published in this issue, takes a new approach to genome analysis. The analysis of 371 tumours revealed 31 recurrent focal events, only six of which were known previously in lung carcinomas. A new candidate oncogene, TITF1, was found to be significant in a large number of lung cancers. This work shows that there are many more important cancer-related genes still undiscovered, and that systematic genomic study can reveal them.

Suggested Citation

  • Barbara A. Weir & Michele S. Woo & Gad Getz & Sven Perner & Li Ding & Rameen Beroukhim & William M. Lin & Michael A. Province & Aldi Kraja & Laura A. Johnson & Kinjal Shah & Mitsuo Sato & Roman K. Tho, 2007. "Characterizing the cancer genome in lung adenocarcinoma," Nature, Nature, vol. 450(7171), pages 893-898, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7171:d:10.1038_nature06358
    DOI: 10.1038/nature06358
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    Cited by:

    1. Yasuhiko Haga & Yoshitaka Sakamoto & Keiko Kajiya & Hitomi Kawai & Miho Oka & Noriko Motoi & Masayuki Shirasawa & Masaya Yotsukura & Shun-Ichi Watanabe & Miyuki Arai & Junko Zenkoh & Kouya Shiraishi &, 2023. "Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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