IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v450y2007i7170d10.1038_nature06347.html
   My bibliography  Save this article

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

Author

Listed:
  • Eric Dessaud

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Lin Lin Yang

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Present address: Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.)

  • Katy Hill

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Barny Cox

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Fausto Ulloa

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Ana Ribeiro

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Anita Mynett

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Bennett G. Novitch

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Present address: Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.)

  • James Briscoe

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

Abstract

Understanding morphogen activity is one of the longest standing problems in developmental biology. Both the duration of exposure to the secreted morphogen Sonic hedgehog (Shh) and the concentration of Shh are important in determining the fate of cells in the neural tube and in the limb bud. This paper clarifies the relationship between time and concentration in Shh signalling during patterning of the neural tube.

Suggested Citation

  • Eric Dessaud & Lin Lin Yang & Katy Hill & Barny Cox & Fausto Ulloa & Ana Ribeiro & Anita Mynett & Bennett G. Novitch & James Briscoe, 2007. "Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism," Nature, Nature, vol. 450(7170), pages 717-720, November.
  • Handle: RePEc:nat:nature:v:450:y:2007:i:7170:d:10.1038_nature06347
    DOI: 10.1038/nature06347
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06347
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature06347?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alek G. Erickson & Alessia Motta & Maria Eleni Kastriti & Steven Edwards & Fanny Coulpier & Emy Théoulle & Aliia Murtazina & Irina Poverennaya & Daniel Wies & Jeremy Ganofsky & Giovanni Canu & Francoi, 2024. "Motor innervation directs the correct development of the mouse sympathetic nervous system," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Chakraborty, Priya & Jolly, Mohit Kumar & Roy, Ushasi & Ghosh, Sayantari, 2023. "Spatio-temporal pattern formation due to host-circuit interplay in gene expression dynamics," Chaos, Solitons & Fractals, Elsevier, vol. 167(C).
    3. Wenxian Wang & Hyeyoung Cho & Jae W. Lee & Soo-Kyung Lee, 2022. "The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    4. Roman Vetter & Dagmar Iber, 2022. "Precision of morphogen gradients in neural tube development," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Seth Teague & Gillian Primavera & Bohan Chen & Zong-Yuan Liu & LiAng Yao & Emily Freeburne & Hina Khan & Kyoung Jo & Craig Johnson & Idse Heemskerk, 2024. "Time-integrated BMP signaling determines fate in a stem cell model for early human development," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:450:y:2007:i:7170:d:10.1038_nature06347. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.