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Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

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  • Xuewu Zhang

    (and Howard Hughes Medical Institute, California Institute for Quantitative Sciences, University of California, Berkeley, California 94720, USA
    Present addresses: Department of Pharmacology and Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas 75390, USA (X.Z.); Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA (R.B.).)

  • Kerry A. Pickin

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Ron Bose

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Present addresses: Department of Pharmacology and Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas 75390, USA (X.Z.); Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA (R.B.).)

  • Natalia Jura

    (and Howard Hughes Medical Institute, California Institute for Quantitative Sciences, University of California, Berkeley, California 94720, USA)

  • Philip A. Cole

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • John Kuriyan

    (and Howard Hughes Medical Institute, California Institute for Quantitative Sciences, University of California, Berkeley, California 94720, USA
    Lawrence Berkeley National Laboratory Berkeley, California 94720, USA)

Abstract

Crystal structures of complexes between the epidermal growth factor receptor (EGFR) kinase domain and a fragment of its feedback inhibitor MIG6 reveal an allosteric inhibition mechanism. MIG6 binds the cyclin/CDK-like asymmetric dimer interface of EGFR and blocks formation of the activating dimer.

Suggested Citation

  • Xuewu Zhang & Kerry A. Pickin & Ron Bose & Natalia Jura & Philip A. Cole & John Kuriyan, 2007. "Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface," Nature, Nature, vol. 450(7170), pages 741-744, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7170:d:10.1038_nature05998
    DOI: 10.1038/nature05998
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    Cited by:

    1. Jung-Yoon Yoo & Tae Hoon Kim & Jung-Ho Shin & Ryan M. Marquardt & Ulrich Müller & Asgerally T. Fazleabas & Steven L. Young & Bruce A. Lessey & Ho-Geun Yoon & Jae-Wook Jeong, 2022. "Loss of MIG-6 results in endometrial progesterone resistance via ERBB2," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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