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p53 regulates maternal reproduction through LIF

Author

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  • Wenwei Hu

    (Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA)

  • Zhaohui Feng

    (Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA)

  • Angelika K. Teresky

    (Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA)

  • Arnold J. Levine

    (Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    The Simons Center for Systems Biology, The Institute for Advanced Study, Princeton, New Jersey 08540, USA)

Abstract

In search of p53's other roles The transcription factor p53 has been studied extensively as a tumour suppressor, but little is known about its normal physiological role. A study in mice now links normal p53 function to reproduction and fertility. A p53 deficiency results in poor implantation of embryos in female mice, low pregnancy rates and small litter sizes. In this role p53 acts by regulating LIF (leukaemia inhibitory factor), a cytokine involved in blastocyst implantation. This work raises the possibility that the normal function of p53 is important for the success of implantation particularly in women undergoing in vitro fertilization or embryo transfer, and suggests a potential strategy to improve implantation efficiency in women with recurrent implantation failure.

Suggested Citation

  • Wenwei Hu & Zhaohui Feng & Angelika K. Teresky & Arnold J. Levine, 2007. "p53 regulates maternal reproduction through LIF," Nature, Nature, vol. 450(7170), pages 721-724, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7170:d:10.1038_nature05993
    DOI: 10.1038/nature05993
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    Cited by:

    1. A. Habibi & N. Farrokhi & F. Morreira da Silva & A. Hosseini & B.F. Bettencourt & F. Amidi, 2013. "Transcript analysis of Heat shock protein 72 and protein 53 of 4-cell mouse embryos following Cryotop vitrification," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 58(5), pages 217-226.
    2. Xiao Han & Baoli Yin & Shengli Lin & Qian Wang & Ni Su & Cuilian Zhang, 2018. "Increased maternal hCG concentrations in early in vitro pregnancy with elevated basal FSH," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-8, September.

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