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Identification of Tim4 as a phosphatidylserine receptor

Author

Listed:
  • Masanori Miyanishi

    (Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
    Department of Genetics,)

  • Kazutoshi Tada

    (Department of Genetics,
    Present address: Mitsubishi UFJ Research and Consulting, Corporate Strategy Consulting Department I, 2-5-8 Emabashi, Chou-ku, Osaka 541-8512, Japan)

  • Masato Koike

    (Osaka University Medical School, Osaka 565-0871, Japan)

  • Yasuo Uchiyama

    (Osaka University Medical School, Osaka 565-0871, Japan)

  • Toshio Kitamura

    (The Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Shigekazu Nagata

    (Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
    Department of Genetics,
    Solution Oriented Research for Science and Technology, Japan Science and Technology Corporation, Kyoto 606-8501, Japan)

Abstract

Apoptosis on the menu During programmed cell death in multicellular organisms, a large number of cells are engulfed by macrophages, thus avoiding the release of noxious materials from the dying cells. These 'apoptotic' cells expose phosphatidylserine (PS) on their surface as an 'eat-me' signal. Miyanishi et al. show that the receptors Tim4 and Tim1 are implicated in phagocyte recognition of PS, while Park et al. show that the BAI1 protein is a receptor for PS in mammalian macrophages.

Suggested Citation

  • Masanori Miyanishi & Kazutoshi Tada & Masato Koike & Yasuo Uchiyama & Toshio Kitamura & Shigekazu Nagata, 2007. "Identification of Tim4 as a phosphatidylserine receptor," Nature, Nature, vol. 450(7168), pages 435-439, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7168:d:10.1038_nature06307
    DOI: 10.1038/nature06307
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    Cited by:

    1. Andrew D. Kraft & G. Jean Harry, 2011. "Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity," IJERPH, MDPI, vol. 8(7), pages 1-39, July.
    2. Joann Chongsaritsinsuk & Alexandra D. Steigmeyer & Keira E. Mahoney & Mia A. Rosenfeld & Taryn M. Lucas & Courtney M. Smith & Alice Li & Deniz Ince & Fiona L. Kearns & Alexandria S. Battison & Marie A, 2023. "Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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