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Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis

Author

Listed:
  • Yuki Okada

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

  • Greg Scott

    (The Knock Out Core,)

  • Manas K. Ray

    (The Knock Out Core,)

  • Yuji Mishina

    (The Knock Out Core,
    Molecular Developmental Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA)

  • Yi Zhang

    (Howard Hughes Medical Institute,
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA)

Abstract

Fertility-linked demethylase The histone H3K9 demethylase JHDM2A was known to play a role in transcriptional activation mediated by the androgen receptor. Now targeted disruption of the Jhdm2a gene in mice shows that the enzyme is involved in spermatogenesis and regulation of transition nuclear protein and protamine genes. This work points to a role for this histone demethylase in the late stages of sperm production and maturation, and Jhdm2a becomes a possible candidate gene for infertility syndromes that have not yet been fully characterized.

Suggested Citation

  • Yuki Okada & Greg Scott & Manas K. Ray & Yuji Mishina & Yi Zhang, 2007. "Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis," Nature, Nature, vol. 450(7166), pages 119-123, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7166:d:10.1038_nature06236
    DOI: 10.1038/nature06236
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    Cited by:

    1. Dongdong Qin & Yayun Gu & Yu Zhang & Shu Wang & Tao Jiang & Yao Wang & Cheng Wang & Chang Chen & Tao Zhang & Weiya Xu & Hanben Wang & Ke Zhang & Liangjun Hu & Lufan Li & Wei Xie & Xin Wu & Zhibin Hu, 2023. "Phase-separated CCER1 coordinates the histone-to-protamine transition and male fertility," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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