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The amniote primitive streak is defined by epithelial cell intercalation before gastrulation

Author

Listed:
  • Octavian Voiculescu

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Federica Bertocchini

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Lewis Wolpert

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Ray E. Keller

    (Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA)

  • Claudio D. Stern

    (University College London, Gower Street, London WC1E 6BT, UK)

Abstract

Gastrulation the movie Gastrulation is a key event in embryogenesis. The mechanisms controlling gastrulation movements in amniotes are not well known and are often extrapolated from studies in other species. Now Voiculescu et al. report the first time-lapse analysis of individual cell movements in living chick embryos during gastrulation. Multi-photon time-lapse microscopy reveals movements that differ from those described in fish and amphibians, with important implications for embryology and evolution of gastrulation in vertebrates. In particular the work reveals an early pregastrulation intercalation event that may hold the key to the classic question of how the amniote primitive streak evolved from the ancestral blastopore.

Suggested Citation

  • Octavian Voiculescu & Federica Bertocchini & Lewis Wolpert & Ray E. Keller & Claudio D. Stern, 2007. "The amniote primitive streak is defined by epithelial cell intercalation before gastrulation," Nature, Nature, vol. 449(7165), pages 1049-1052, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7165:d:10.1038_nature06211
    DOI: 10.1038/nature06211
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    Cited by:

    1. Nigel C Harrison & Ruth Diez del Corral & Bakhtier Vasiev, 2011. "Coordination of Cell Differentiation and Migration in Mathematical Models of Caudal Embryonic Axis Extension," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-18, July.
    2. Julio M Belmonte & Maciej H Swat & James A Glazier, 2016. "Filopodial-Tension Model of Convergent-Extension of Tissues," PLOS Computational Biology, Public Library of Science, vol. 12(6), pages 1-20, June.
    3. Bakhtier Vasiev & Ariel Balter & Mark Chaplain & James A Glazier & Cornelis J Weijer, 2010. "Modeling Gastrulation in the Chick Embryo: Formation of the Primitive Streak," PLOS ONE, Public Library of Science, vol. 5(5), pages 1-14, May.

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