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Interferon modulation of cellular microRNAs as an antiviral mechanism

Author

Listed:
  • Irene M. Pedersen

    (Department of Molecular Biology,)

  • Guofeng Cheng

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Stefan Wieland

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Stefano Volinia

    (Immunology & Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA)

  • Carlo M. Croce

    (Immunology & Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA)

  • Francis V. Chisari

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Michael David

    (Department of Molecular Biology,
    Moores Cancer Center, University of California San Diego, La Jolla, California 92093, USA)

Abstract

Antiviral miRNA Plants and invertebrates can use RNA silencing as a protective mechanism in viral infection. Now cellular microRNAs (miRNAs) have been found to have an antiviral function in mammalian cells too. Interferon-β is involved in the regulation of a number of cellular miRNAs in human cells, and eight of these are active against sequences on the hepatitis C virus. In addition, modulation of cellular miRNA levels are found to contribute significantly towards the antiviral effects of interferon-β, suggesting that they are a functioning component of the mammalian innate immune response.

Suggested Citation

  • Irene M. Pedersen & Guofeng Cheng & Stefan Wieland & Stefano Volinia & Carlo M. Croce & Francis V. Chisari & Michael David, 2007. "Interferon modulation of cellular microRNAs as an antiviral mechanism," Nature, Nature, vol. 449(7164), pages 919-922, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7164:d:10.1038_nature06205
    DOI: 10.1038/nature06205
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    Cited by:

    1. Emilie Estrabaud & Kevin Appourchaux & Ivan Bièche & Fabrice Carrat & Martine Lapalus & Olivier Lada & Michelle Martinot-Peignoux & Nathalie Boyer & Patrick Marcellin & Michel Vidaud & Tarik Asselah, 2015. "IFI35, mir-99a and HCV Genotype to Predict Sustained Virological Response to Pegylated-Interferon Plus Ribavirin in Chronic Hepatitis C," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-19, April.

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