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The equilibria that allow bacterial persistence in human hosts

Author

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  • Martin J. Blaser

    (New York University School of Medicine, New York, New York 10016, USA)

  • Denise Kirschner

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

Abstract

Getting to know you Microbial persistence in hosts is usually not accidental, but reflects a shared merging of the biology of two or more disparate life-forms. Martin Blaser and Denise Kirschner advance the hypothesis that there has been selection for both microbes and hosts to maximize the fitness of both parties to a life involving parasitism or symbiosis, conforming to an evolutionarily stable strategy. They develop a model that can account for the persistence of three very different types of interaction between microbes in humans — involving Helicobacter pylori, Salmonella typhi and Mycobacterium tuberculosis.

Suggested Citation

  • Martin J. Blaser & Denise Kirschner, 2007. "The equilibria that allow bacterial persistence in human hosts," Nature, Nature, vol. 449(7164), pages 843-849, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7164:d:10.1038_nature06198
    DOI: 10.1038/nature06198
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    Cited by:

    1. Sandeepa M Eswarappa, 2009. "Location of Pathogenic Bacteria during Persistent Infections: Insights from an Analysis Using Game Theory," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-4, April.
    2. Gi Young Lee & Jeongmin Song, 2024. "Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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